{"product_id":"abcam-ab313979","title":"Abcam, ab313979, Human Kallikrein 15 ELISA Kit","description":"\u003cp\u003eSize: 1 x 96Tests\u003cbr\u003e\nHuman Kallikrein 15 ELISA Kit is a Sandwich (quantitative) ELISA for the measurement of Human Kallikrein 15 in Human in Biofluids, Cell Culture Media samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nDetection method:Colorimetric,\u003cbr\u003e\nSample types:Serum, Plasma, Cell culture supernatant,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nAssay type:Sandwich (quantitative),\u003cbr\u003e\nSensitivity:= 22 pg\/mL,\u003cbr\u003e\nRange:22 - 5000 pg\/mL,\u003cbr\u003e\nAssay Platform:Pre-coated microplate (12 x 8 well strips)\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nHuman Kallikrein 15 ELISA Kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of human Kallikrein 15 in serum, plasma and cell culture supernatants. This assay employs an antibody specific for human Kallikrein 15 coated on a 96-well plate.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Blue Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information--20°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nKallikrein 15 (KLK15) is a serine protease known for its involvement in various physiological processes. This protein has a molecular mass of about 27-28 kDa. KLK15 is part of the kallikrein family and it is often found expressed in tissues such as the prostate uterus and colon. Due to its expression pattern KLK15 is sometimes referred to by alternative names but they are mostly related to tissue-specific variations. The mechanical function involves proteolytic activity where it cleaves peptide bonds in protein substrates.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nKLK15 plays a role in processes like tissue remodeling and can influence cell migration or invasion. As part of the serine protease family it does not just work in isolation but interacts within a network of proteins. There are suggestions of it forming complexes especially with other kallikreins affecting their activity within the local environmental contexts like the extracellular matrix. These actions highlight the biological significance of KLK15 beyond simple catalytic activity.\u003cbr\u003e\nPathways\u003cbr\u003e\nKLK15 participates in the proteolytic cascade pathways. It is closely linked with pathways involved in inflammation and tissue homeostasis. Through these pathways KLK15 interacts with proteins such as kallikrein-related peptidases that share regulatory mechanisms and overlapping substrate specificities. These interactions suggest a role in signaling pathways that regulate cellular responses to environmental changes further linking KLK15 to broader physiological functions.\u003cbr\u003e\nKLK15 has been associated with prostate cancer and ulcerative colitis. Its expression levels can serve as a biomarker for the diagnosis and progression of prostate cancer highlighting its clinical utility. In prostate cancer KLK15 frequently interacts with proteins like KLK3 also known as prostate-specific antigen (PSA) which is instrumental in managing patient prognosis. Additionally in the context of ulcerative colitis changes in KLK15 expression levels could also provide insight into disease mechanisms or progression although the precise interactions remain an area for further investigation.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46843787215017,"sku":"ab313979","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab313979","provider":"Iright","version":"1.0","type":"link"}