{"product_id":"abcam-ab314388","title":"Abcam, ab314388, Human SCGF ELISA Kit","description":"\u003cp\u003eSize: 1 x 96Tests\u003cbr\u003e\nHuman SCGF ELISA Kit is a Sandwich (quantitative) ELISA for the measurement of Human SCGF in Human in Biofluids, Cell Culture Media samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nDetection method:Colorimetric,\u003cbr\u003e\nSample types:Serum, Plasma, Cell culture supernatant,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nAssay type:Sandwich (quantitative),\u003cbr\u003e\nSensitivity:= 0.038 ng\/mL,\u003cbr\u003e\nRange:0.038 - 10 ng\/mL,\u003cbr\u003e\nAssay Platform:Pre-coated microplate (12 x 8 well strips)\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nHuman SCGF ELISA Kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of human SCGF in serum, plasma and cell culture supernatants. This assay employs an antibody specific for human SCGF coated on a 96-well plate.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Blue Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information--20°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nStem Cell Growth Factor (SCGF) also known as C-type lectin domain family 11 member A (CLEC11A) is a glycoprotein with a mass around 38 kDa. It mechanically functions by promoting mitogenic and survival activities on hematopoietic progenitors which are essential for blood cell formation. SCGF is mainly expressed in the bone marrow as well as in several other tissues such as the pancreas and liver where it plays significant roles.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nSCGF plays a significant role in the development and regulation of the hematopoietic system. It supports the proliferation and differentiation of a variety of blood cell lineages. SCGF does not belong to a complex but interacts with other soluble factors like cytokines and growth factors to exert its functions. It enhances the actions of colony-stimulating factors emphasizing its role in hematopoiesis.\u003cbr\u003e\nPathways\u003cbr\u003e\nSCGF is important in the regulation of the hematopoietic growth pathways. It is involved in the cytokine-cytokine receptor interaction pathway which assists in signaling and communication between cells. SCGF shows interactions with proteins like FLT3 which play a role in the development and survival of blood cell precursors. This intricate network bolsters the adaptive and innate immune systems by promoting the production and function of necessary blood cells.\u003cbr\u003e\nDisruptions in SCGF activity can influence both hematological and autoimmune disorders. Alterations in SCGF expression have connections to leukemia where abnormal proliferation of blood cells occurs. Additionally its dysregulation may contribute to autoimmune diseases where the immune system mistakenly attacks the body. In these contexts SCGF relates with the cytokine IL-6 which is also involved in immune responses and inflammation further underlining SCGF's influence on disease mechanisms.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46843786657961,"sku":"ab314388","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab314388","provider":"Iright","version":"1.0","type":"link"}