{"product_id":"abcam-ab314499","title":"Abcam, ab314499, Anti-NLRP6 antibody [EPR28233-48] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal NLRP6 antibody. Carrier free. Suitable for WB and reacts with Mouse, Rat, Transfected cell lysate - Human samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR28233-48,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Mouse, Rat,\u003cbr\u003e\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab314499 is the carrier-free version of\u003cbr\u003e\nab314498\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nNLRP6 also known as NACHT LRR and PYD domain-containing protein 6 plays a role as a sensor in the immune system. This protein has a mass of approximately 109 kDa. It is expressed in multiple tissues with high levels in intestinal cells and immune-related tissues. NLRP6 functions as part of the inflammasome complex which is important for inducing inflammatory responses by activating caspase-1 and promoting the maturation of inflammatory cytokines such as IL-1β and IL-18.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nNLRP6 has significant roles in maintaining mucosal homeostasis and modulating the body's inflammatory responses. It forms part of the NLRP6 inflammasome complex which impacts immune homeostasis especially within the gut environment. Research indicates that NLRP6 influences both the regulation of the microbiota and the repair processes of the mucosal barrier making it essential for gut health and protection against infections.\u003cbr\u003e\nPathways\u003cbr\u003e\nNLRP6 influences both inflammation and metabolic pathways offering insights into its broad function in immunity. It is a part of the inflammasome pathway which triggers the immune system to combat bacterial infections by activating cytokines. The protein interacts with other inflammasome components like ASC and caspase-1. Additionally NLRP6 is involved in the toll-like receptor (TLR) signaling pathway influencing signal transduction related to immune responses.\u003cbr\u003e\nDefects in NLRP6 have been linked to inflammatory bowel diseases (IBD) and colitis. Studies show that alterations in NLRP6 function may disrupt gut microbiota balance leading to increased susceptibility to these diseases. Additionally altered NLRP6 activity can connect to colorectal cancer especially with proteins like NF-κB suggesting that its pathways play a role in tumorigenesis by affecting inflammation and immune responses.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46852282089641,"sku":"ab314499","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab314499","provider":"Iright","version":"1.0","type":"link"}