{"product_id":"abcam-ab314714","title":"Abcam, ab314714, Human TSG6 ELISA Kit","description":"\u003cp\u003eSize: 1 x 96Tests\u003cbr\u003e\nHuman TSG6 ELISA Kit is a Sandwich (quantitative) ELISA for the measurement of Human TSG6 in Human in Cell Culture Media, Biofluids samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nDetection method:Colorimetric,\u003cbr\u003e\nSample types:Cell culture supernatant, Plasma, Serum,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nAssay type:Sandwich (quantitative),\u003cbr\u003e\nSensitivity:= 0.2 ng\/mL,\u003cbr\u003e\nRange:0.2 - 50 ng\/mL,\u003cbr\u003e\nAssay Platform:Pre-coated microplate (12 x 8 well strips)\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nHuman TSG6 ELISA kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of human TSG6 in serum, plasma and cell culture supernatants. This assay employs an antibody specific for human TSG6 coated on a 96-well plate.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Blue Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information--20°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nTSG6 also known as tumor necrosis factor-inducible gene 6 protein plays an important role in inflammation and tissue repair. This protein has a molecular mass of approximately 35 kDa. TSG6 expresses in various tissues especially in response to inflammation or tissue injury. Such expression is significant in cells like macrophages and fibroblasts as well as in tissues like the synovial lining and skin.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nTSG6 contributes to the modulation of the inflammatory response and tissue remodeling. It does this by interacting with molecules such as hyaluronan which is an important component of the extracellular matrix. During inflammatory responses TSG6 forms a complex with inter-α-inhibitor a serine protease inhibitor enhancing its stability and function. Through these interactions TSG6 helps to regulate the extracellular environment during tissue repair processes.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe protein TSG6 participates actively in the inflammatory pathway and the hyaluronan metabolism pathway. It influences inflammatory events by modulating the activity of inflammatory cytokines affecting processes like leukocyte recruitment. TSG6 works closely with proteins such as TNF-α and IL-1 both integral to the inflammatory response. In the hyaluronan pathway TSG6 influences the structural organization of the matrix affecting cell migration and adhesion.\u003cbr\u003e\nTSG6 relates to conditions like osteoarthritis and rheumatoid arthritis. In these disorders inflammation and tissue degradation play central roles. TSG6 interacts with proteins like matrix metalloproteinases which are involved in tissue breakdown and remodeling. By modulating these interactions TSG6 can potentially influence disease progression or resolution making it an interesting target for therapeutic intervention in inflammatory diseases.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46843761819817,"sku":"ab314714","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab314714","provider":"Iright","version":"1.0","type":"link"}