{"product_id":"abcam-ab314830","title":"Abcam, ab314830, Human CD314 ELISA Kit","description":"\u003cp\u003eSize: 1 x 96Tests\u003cbr\u003e\nHuman CD314 ELISA Kit is a Sandwich (quantitative) ELISA for the measurement of Human CD314 in Human in Biofluids, Cell Culture Media samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nDetection method:Colorimetric,\u003cbr\u003e\nSample types:Serum, Plasma, Cell culture supernatant,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nAssay type:Sandwich (quantitative),\u003cbr\u003e\nSensitivity:= 0.4 ng\/mL,\u003cbr\u003e\nRange:0.4 - 100 ng\/mL,\u003cbr\u003e\nAssay Platform:Pre-coated microplate (12 x 8 well strips)\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nHuman CD314 ELISA Kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of human CD314 in serum, plasma and cell culture supernatants. This assay employs an antibody specific for human CD314 coated on a 96-well plate.\u003cbr\u003e\nThis ELISA kit shows no cross-reactivity with the following cytokines tested: human Adenosine Deaminase\/ADA, AIF, AKR1C4 , ASAH2, BCL-2, BID, Calreticulin, Calreticulin-2, CD39L3\/ENTPD3, CD51, CD99-L2, CDC25B, Cerberus 1, CHST2, Cochlin, CRELD2, DCSIGNR\/CD299, eNOS, ENPP2\/Autotaxin, FABP4, Fc epsilon RI, FGF R5, GALNT2, GALNT3, GIF, GPR111, beta-Glucuronidase\/GUSB, Inhibin A, LILRB4\/CD85k\/ILT3, Neuroglycan C\/CSPG5, NKp46\/NCR1, Neuronal Pentraxin R\/NPTXR, ROR2, SCCA2, Siglec2\/CD22, SIRP alpha\/CD172a, SorCS1, Trypsin 1\/PRSS1, Trypsin 3\/PRSS3.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Blue Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information--20°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nNKG2D also known as natural killer group 2 member D is a type-2 transmembrane receptor with a mass of approximately 42 kDa. Expressed primarily on natural killer (NK) cells CD8+ T cells subsets of CD4+ T cells and some macrophages it recognizes stress-induced ligands presented on target cells. This protein plays an important role in the immune system's recognition and elimination of infected or transformed cells by binding to its ligands which include MHC class I chain-related proteins MICA\/B and UL16-binding proteins.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nNKG2D acts as an activating receptor on the cell surface that initiates immune responses leading to cytotoxicity against target cells. It functions as part of a complex involving the adaptor protein DAP10 which transduces activating signals to promote cellular immune responses. This interaction amplifies the activation of immune cells and contributes to the host's defense against tumors and virally infected cells.\u003cbr\u003e\nPathways\u003cbr\u003e\nNKG2D plays a significant role in immune surveillance and signaling pathways. It actively involves in the natural killer (NK) cell-mediated cytotoxicity pathway and the adaptive immune response pathway. The interaction with proteins such as DAP10 is critical for its signaling function contributing to its interaction within these pathways. The signaling through NKG2D directly affects the activation states and responses of immune cells which are vital in immune defense.\u003cbr\u003e\nNKG2D is implicated in cancer and autoimmune diseases. In cancer overexpression of its ligands on tumor cells makes them susceptible to NKG2D-mediated cell lysis. On the other hand aberrant expression of NKG2D ligands in autoimmune disorders can lead to inappropriate immune activation. The interaction with MICA\/B proteins is significant in these conditions emphasizing its importance in both immune surveillance and potential disease pathogenesis.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46855678525609,"sku":"ab314830","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab314830","provider":"Iright","version":"1.0","type":"link"}