{"product_id":"abcam-ab314864","title":"Abcam, ab314864, Anti-HMGN1 antibody [EPR26772-17]","description":"\u003cp\u003eSize: 20µL \/ 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal HMGN1 antibody. Suitable for IHC-P, ICC\/IF, Flow Cyt (Intra), IP and reacts with Human, Transfected cell line - Human samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR26772-17,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IP, Flow Cyt (Intra), IHC-P, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.,\u003cbr\u003e\nSpecificity:This antibody does not cross-react with human HMGN2, HMGN3, HMGN4, HMGN5.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nHMGN1 also known as high mobility group nucleosomal binding domain protein 1 is a non-histone chromosomal protein with a mass of approximately 11 kDa. It interacts with chromatin inside the nucleus and regulates the architecture of nucleosomes. HMGN1 expresses in various types of tissues with higher levels observed in actively proliferating cells. The protein modulates the structure of chromatin by binding to nucleosomes and affecting nucleosome spacing and histone modifications.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThis protein plays an important role in modulating gene expression and cellular response to DNA damage. It does not form part of a large complex but associates with nucleosomes to influence chromatin dynamics. HMGN1 can affect transcription by altering chromatin accessibility and stabilizer that facilitates repair processes in response to DNA damage. The protein can also interfere with specific transcription factors therefore reducing or enhancing the transcription of target genes.\u003cbr\u003e\nPathways\u003cbr\u003e\nThis protein fits into cellular pathways involving transcription regulation and DNA repair. HMGN1 modifies chromatin structure and therefore participates in transcription-related pathways. It is also involved in DNA repair pathways ensuring proper response to DNA damage. Within these systems HMGN1 interacts with proteins such as HMGA1 influencing transcription and ATM which is critical in the DNA damage response pathway.\u003cbr\u003e\nIrregular expression or dysfunction of this protein links to certain cancers and autoimmune disorders. HMGN1 influences the development and progression of diseases through its role in gene expression and chromatin modulation. Aberrations in HMGN1 expression can lead to improper regulation of related proteins such as p53 an important player in cancer progression and NF-kB involved in immune responses. This connection with p53 and NF-kB makes HMGN1 a target of interest in disease research and therapy development.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850366144681,"sku":"ab314864","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab314864","provider":"Iright","version":"1.0","type":"link"}