{"product_id":"abcam-ab315333","title":"Abcam, ab315333, Anti-CPEB4 antibody [EPR27416-141] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nKnockout Tested Rabbit Recombinant Monoclonal CPEB4 antibody. Carrier free. Suitable for WB, ICC\/IF, IP, IHC-Fr, Flow Cyt (Intra) and reacts with Human, Mouse, Rat samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR27416-141,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human, Mouse, Rat,\u003cbr\u003e\nApplications:ICC\/IF, IHC-Fr, Flow Cyt (Intra), WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab315333 is the carrier-free version of\u003cbr\u003e\nab315332\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nCPEB4 also known as Cytoplasmic Polyadenylation Element Binding Protein 4 plays an important role in post-transcriptional regulation specifically in mRNA polyadenylation. This protein with a molecular weight of about 75 kDa is part of the CPEB family. Researchers have discovered its expression in various tissues including the brain and testes where it binds mRNA to control translation during processes like oocyte maturation and synaptic plasticity.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe protein influences gene expression by modulating mRNA stability and translational efficiency. CPEB4 is not isolated in function; it interacts with other proteins as a part of the cytoplasmic polyadenylation complex. Through these interactions CPEB4 affects cell cycle progression stress responses and neuronal development therefore integrating environmental signals into cellular responses.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe function of CPEB4 fits into critical signaling routes including the MAPK and PI3K-AKT pathways. Within these pathways CPEB4 interacts with proteins like MEK and AKT impacting cell survival growth and differentiation. The protein modulates mRNA translation in response to signaling cues serving as a conduit for transmitting intracellular messages that dictate cellular adaptation and response.\u003cbr\u003e\nResearchers have linked CPEB4 to conditions such as cancer and neurodegenerative diseases. In glioblastoma for example the protein's aberrant expression affects tumorigenesis pathways often in conjunction with proteins like P53 to manipulate cell proliferation and survival. In neurodegenerative conditions alterations in CPEB4 can impact proteins involved in synaptic maintenance thereby contributing to cognitive decline and neural dysfunction.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851629056169,"sku":"ab315333","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab315333","provider":"Iright","version":"1.0","type":"link"}