{"product_id":"abcam-ab316198","title":"Abcam, ab316198, Anti-Ajuba antibody [EPR27503-126] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal AJUBA antibody. Carrier free. Suitable for WB and reacts with Human, Mouse samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR27503-126,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human, Mouse,\u003cbr\u003e\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab316198 is the carrirer-free version of\u003cbr\u003e\nab316197\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nAjuba also known as Juba or 8 Ajuba is a LIM domain protein with a molecular mass of around 55 kDa. This protein shows expression in various tissues including the skin and immune cells. Mechanically Ajuba functions as a scaffold protein interacting with several other proteins to regulate cellular processes. It helps in the assembly and stabilization of protein complexes especially at the cell surface and in the nucleus playing an important role in connecting cytoskeletal components to signaling pathways.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nAjuba influences cell proliferation adhesion and migration. As part of the Ajuba-Zyxin-LIMD1 complex it interacts with actin filaments and diverse cytoskeletal proteins mediating signal transduction from extracellular cues to the nucleus. Through these interactions Ajuba modulates gene expression essential for cell cycle progression and differentiation emphasizing its significance in development and tissue maintenance.\u003cbr\u003e\nPathways\u003cbr\u003e\nAjuba participates in the Wnt signaling and the Hippo pathway. Within Wnt signaling Ajuba partners with key proteins like β-catenin to regulate transcriptional activity and cell fate determination. Additionally in the Hippo pathway Ajuba associates with large tumor suppressor kinases (LATS) and YAP influencing cellular growth and apoptosis. These pathways demonstrate Ajuba's involvement in maintaining cellular homoeostasis and response to environmental stimuli.\u003cbr\u003e\nAjuba's dysregulation associates with cancer and autoimmune diseases. In cancer altered Ajuba expression affects cell survival and proliferation tying it to proteins such as β-catenin in colorectal cancer progression. In autoimmune diseases improper Ajuba functioning disrupts immune cell signaling and tolerance impacting proteins like NF-kB. These connections highlight Ajuba's role in pathological conditions and its potential as a therapeutic target.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46852533715113,"sku":"ab316198","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab316198","provider":"Iright","version":"1.0","type":"link"}