{"product_id":"abcam-ab317139","title":"Abcam, ab317139, Anti-SEMA6A antibody [HL2120]","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Monoclonal Sema6A antibody. Suitable for WB and reacts with Human, Mouse, Rat samples. Immunogen corresponding to Recombinant Fragment Protein within Human SEMA6A.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:HL2120,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human, Mouse, Rat,\u003cbr\u003e\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human SEMA6A.Q9H2E6\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Storage buffer-pH: 7.4 Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nSemaphorin 6A also known as Sema6A is a transmembrane protein that plays a significant role in axon guidance and cell signaling. It has a mass of approximately 95 kDa and is a member of the semaphorin protein family. Sema6A is expressed mainly in the nervous system but also found in other tissues like the heart and kidney. In neuronal cells it interacts with plexin receptors to guide axonal pathways influencing the growth cone dynamics during neural development.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nSema6A plays a role in cellular navigation during neural development. It functions as a signaling cue that aids in cell positioning by influencing the structure and orientation of the cellular cytoskeleton. Although not part of a large protein complex itself Sema6A can interact with plexins to modulate other cellular pathways. The interactions help manage axonal growth and directionality essential for proper neural circuit formation.\u003cbr\u003e\nPathways\u003cbr\u003e\nSema6A significantly influences the axon guidance and neural crest cell migration pathways. In these pathways it interacts with proteins such as plexin-A4 which play key roles in transducing semaphorin signals to the cytoskeleton. By guiding axonal direction Sema6A integrates into neural development processes as well as affecting the migration of neurons and their interaction within different tissues.\u003cbr\u003e\nSema6A is associated with neurodevelopmental disorders and cancer metastasis. Mutations or dysregulation within Sema6A signaling can contribute to conditions such as autism spectrum disorder where it may affect neural connectivity. In cancer irregular expression of Sema6A might influence tumor progression and metastasis by interacting with plexin receptors changing cell adhesion properties and impacting cell migration.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850343764137,"sku":"ab317139","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab317139","provider":"Iright","version":"1.0","type":"link"}