{"product_id":"abcam-ab317141","title":"Abcam, ab317141, Anti-GSX2 antibody [HL2135]","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Monoclonal antibody. Suitable for WB, ICC\/IF and reacts with Transfected cell lysate, Rat samples. Immunogen corresponding to Recombinant Fragment Protein within Human GSX2.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:HL2135,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Rat,\u003cbr\u003e\nApplications:ICC\/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human GSX2.Q9BZM3\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nGSH2 also known as glutathione synthetase 2 adds up to gamma-glutamylcysteine to create glutathione a tripeptide important in cellular defense against oxidative stress. It has a molecular mass of approximately 52 kDa. GSH2 shows expression in various tissues with higher levels in the liver and kidneys due to their roles in detoxification processes.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe role of GSH2 involves maintaining intracellular redox balance and detoxifying harmful substances. GSH2 works closely with glutamate-cysteine ligase in the synthesis of glutathione. As part of the larger antioxidant system GSH2 ensures cells are protected from damage caused by reactive oxygen species.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe glutathione synthesis pathway relies heavily on GSH2's activity influencing the glutathione metabolism pathway. This pathway is critical for antioxidant defense and various metabolic processes. GSH2 closely interacts with enzymes like glutathione reductase and glutathione peroxidase emphasizing its importance in maintaining cellular homeostasis.\u003cbr\u003e\nGSH2 mutations or dysregulation can lead to conditions such as glutathione synthetase deficiency and oxidative stress-related disorders. These conditions often involve impaired glutathione metabolism linking GSH2 to neurological and metabolic dysfunctions. GSH2 mutations affect proteins like catalase and superoxide dismutase resulting in reduced efficiency in combating oxidative stress.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850361917609,"sku":"ab317141","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab317141","provider":"Iright","version":"1.0","type":"link"}