{"product_id":"abcam-ab319381","title":"Abcam, ab319381, PE Anti-4R Tau antibody [EPR21725]","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Recombinant Monoclonal TAU antibody - conjugated to PE.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR21725,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nConjugation:PE,\u003cbr\u003e\nExcitation\/Emission:Ex: 480;565nm, Em: 578nm,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nApplications:Antibody Labelling, Target Binding AffinitySee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nHow are conjugated primary antibodies validated?\u003cbr\u003e\nThis conjugated primary antibody is released using a quantitative quality control method that evaluates binding affinity post-conjugation and efficiency of antibody labeling.\u003cbr\u003e\nFor suitable applications and species reactivity, please refer to the unconjugated version of this clone.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle|Store in the dark\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\n4R Tau also known as the 4-repeat tau protein plays a significant role in the stabilization of microtubules in neurons. This protein appears mainly in the human central nervous system where it assists in axonal structure and transport. 4R Tau has a molecular weight of approximately 65 kDa. The expression of 4R Tau occurs mostly in neurons although its presence can also be detected in other cell types within the brain.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\n4R Tau is a component essential for the assembly and maintenance of neuronal microtubules. It regulates microtubule dynamics by binding and enhancing their stability important for maintaining cellular and axonal integrity. In mature neurons 4R Tau exists as part of a complex with tubulin forming an important element for axonal morphology. Its function extends further into modulating neuronal growth and signal transmission which directly impacts neural connectivity.\u003cbr\u003e\nPathways\u003cbr\u003e\n4R Tau is integral within the microtubule-associated protein tau (MAPT) signaling pathways. It interacts with other proteins that influence microtubule assembly and stability such as tubulin and MAP2 playing a significant role in cytoskeletal development. Additionally 4R Tau is involved in the protein folding pathways regulated by chaperones like Heat Shock Protein 70 (Hsp70) which affect its aggregation and function within neural cells.\u003cbr\u003e\n4R Tau is closely associated with neurodegenerative conditions such as Alzheimer's disease and frontotemporal dementia. Aberrant phosphorylation and aggregation of 4R Tau drive pathological tau tangles which disrupt neural networks and lead to cognitive decline. In Alzheimer’s the protein's dysfunction is linked with amyloid-beta peptide which accelerates tau pathology progression. Similarly in frontotemporal dementia 4R Tau's abnormal activity is influenced by interactions with proteins such as TDP-43 highlighting its central role in these neurodegenerative disorders.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847793987753,"sku":"ab319381","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab319381","provider":"Iright","version":"1.0","type":"link"}