{"product_id":"abcam-ab320639","title":"Abcam, ab320639, Anti-CAMK2B\/2D\/2G (phospho T287) + CAMK2A (phospho T286) antibody [EPR28075-37] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal KCC2B phospho T287 antibody. Carrier free. Suitable for WB, Dot and reacts with Transfected cell lysate - Human, Human, Mouse, Rat, Synthetic peptide samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR28075-37,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human, Mouse, Rat,\u003cbr\u003e\nApplications:WB, DotSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab320639 is the carrier-free version of\u003cbr\u003e\nab320638\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe CaMKII (Ca2+\/calmodulin-dependent protein kinase II) family consists of four isoforms: CaMKII alpha CaMKII beta CaMKII delta and CaMKII gamma also known respectively as CAMK2A CAMK2B CAMK2D and CAMK2G. These are serine\/threonine-specific protein kinases with a molecular weight of around 50 to 60 kDa. They play a role in the phosphorylation of various downstream targets. These kinases are found in many tissues but CaMKII alpha is mostly found in brain tissue CaMKII beta in muscle tissue whereas CaMKII delta and gamma show more widespread expression across other tissues. The functional unit of CaMKII is a holoenzyme which forms a dodecamer consisting of 12 subunits.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nCaMKII isoforms participate in critical calcium signaling processes. They act to decode the frequency of calcium oscillations in cells and are involved in synaptic plasticity and memory formation. CaMKII alpha for example is highly active in the postsynaptic density where it can form complexes with both NMDA and AMPA receptors suggesting a role in the regulation of synaptic strength. While not part of a permanent complex CaMKII enzymes can transiently bind to other proteins during signaling events.\u003cbr\u003e\nPathways\u003cbr\u003e\nCaMKII isoforms play significant roles in the calcium\/calmodulin signal transduction pathway and the MAPK (mitogen-activated protein kinase) signaling cascade. In the calcium\/calmodulin pathway CaMKII acts to mediate calcium-dependent phosphorylation events that affect neuronal and cardiac functions. It interacts with other pathway proteins such as calmodulin and CREB (cAMP response element-binding protein). In the MAPK pathway CaMKII modulates signals that control cell growth differentiation and response to cellular stress interacting with proteins like MEK and ERK.\u003cbr\u003e\nCaMKII isoforms have connections to neurodegenerative diseases such as Alzheimer's disease and to cardiac conditions like heart failure. In Alzheimer's disease altered CaMKII activity can affect synaptic function linking to proteins like amyloid-beta peptides. In cardiac disorders abnormal CaMKII activation contributes to disrupted calcium homeostasis and arrhythmia where it interacts with proteins such as RyR2 (ryanodine receptor 2). Understanding these interactions highlights CaMKII's significance in both brain and heart health.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46860576948393,"sku":"ab320639","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab320639","provider":"Iright","version":"1.0","type":"link"}