{"product_id":"abcam-ab3341","title":"Abcam, ab3341, Anti-Ubiquilin\/UBQLN1 antibody","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nRabbit Polyclonal Ubiquilin\/UBQLN1 antibody. Suitable for IHC-P, WB and reacts with Mouse, Human, Chinese hamster samples. Cited in 8 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Human, Chinese hamster,\u003cbr\u003e\nApplications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-Constituents: PBS, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nUbiquilin also known as UBQLN1 is a protein that plays a significant role in protein quality control processes. It has a molecular mass of approximately 62 kDa. Ubiquilin is widely expressed in various human tissues notably in the brain heart and skeletal muscle. It facilitates the delivery of misfolded proteins to the proteasome for degradation assisting in maintaining protein homeostasis. This function is essential in preventing the accumulation of dysfunctional proteins which could otherwise be toxic to cells.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nUbiquilin\/UBQLN1 serves as a shuttle factor a component in the intricate network regulating protein degradation. It associates with ubiquitinated proteins and guides them to proteasomes or autophagosomes for disposal. Moreover Ubiquilin forms a complex with heat shock proteins and proteasome components enhancing its role in managing cellular protein quality control. Its activity actively influences proteostasis ensuring the careful balance of protein synthesis and breakdown.\u003cbr\u003e\nPathways\u003cbr\u003e\nUbiquilin\/UBQLN1 is integral to the ubiquitin-proteasome system and autophagy pathways. In these pathways Ubiquilin partners with proteins such as ubiquitin ligases and various adaptor proteins to mediate the clearance of misfolded or excess proteins therefore preventing cellular damage. Its interaction with the chaperone HSP70 is critical for delivering proteins tagged for degradation. Through these pathways Ubiquilin influences cellular stress responses and protein turnover maintaining cellular function and health.\u003cbr\u003e\nAbnormalities in Ubiquilin\/UBQLN1 have been associated with neurodegenerative diseases and cancer. Altered UBQLN1 function or expression contributes to Alzheimer's disease linked to protein aggregation and neuronal damage. Additionally mutations or dysregulation of UBQLN1 are observed in certain cancers where disrupted protein homeostasis promotes tumorigenesis. Here it's involvement with proteins like presenilin-1 and the amyloid precursor protein emphasizes its contributions to disease states making it a focus for therapeutic research.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850089386153,"sku":"ab3341","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab3341","provider":"Iright","version":"1.0","type":"link"}