{"product_id":"abcam-ab34668","title":"Abcam, ab34668, Anti-ULP-1 antibody","description":"\u003cp\u003eSize: 500µg\u003cbr\u003e\nRabbit Polyclonal SpUlp1 antibody. Suitable for ICC\/IF, WB, ELISA and reacts with Saccharomyces cerevisiae samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Saccharomyces cerevisiae S288C ULP1.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Saccharomyces cerevisiae,\u003cbr\u003e\nApplications:WB, ELISA, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Full Length Protein corresponding to Saccharomyces cerevisiae S288C ULP1.Q02724\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purity-IgG fraction, Purification technique-Ion exchange chromatography, Purification notes-This product is an IgG fraction antibody purified from monospecific antiserum by a multi-step process which includes delipidation, salt fractionation and ion exchange chromatography followed by extensive dialysis against the buffer., Storage buffer-Preservative: 0.01% Sodium azideConstituents: 0.88% Sodium chloride, 0.424% Potassium phosphate solution, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nSpUlp1 also known as Ulp1p or Ubl-specific protease 1 is a SUMO-specific protease that has a mass of approximately 80 kDa. It catalyzes the deconjugation of small ubiquitin-like modifier (SUMO) proteins from various substrate proteins. This enzymatic action is important for maintaining protein functionality within the cell. SpUlp1 is expressed in a variety of eukaryotic cells where it localizes to the nuclear envelope and is involved in the dynamic process of SUMO modification.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe activity of this protease maintains cellular protein homeostasis through reverting sumoylated proteins back to their unmodified states influencing a broad range of cellular functions. SpUlp1 forms part of the SUMO modification pathway and interacts with several other components of the SUMO machinery. Its action serves to modulate processes such as nuclear transport transcription and signal transduction which are essential for cell cycle progression and stress responses.\u003cbr\u003e\nPathways\u003cbr\u003e\nSUMO modification heavily involving SpUlp1 integrates into gene expression regulation and DNA damage repair mechanisms. It operates in the SUMOylation pathway critically impacting processes by interacting with proteins like RanGAP1 and p53. These interactions allow cellular machinery to appropriately respond to environmental and intracellular cues influencing cell survival and repair pathways.\u003cbr\u003e\nAbnormalities in SpUlp1 activity relate to cancer and neurodegenerative diseases. Altered SUMOylation impacts cellular stress responses and apoptosis factors associated with tumorigenesis and the progression of diseases like Alzheimer's. The target is connected to proteins p53 and tau implicated in these conditions where dysregulation leads to aberrant cell cycle progression and aggregation of neurotoxic proteins.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854239977641,"sku":"ab34668","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab34668","provider":"Iright","version":"1.0","type":"link"}