{"product_id":"abcam-ab34733","title":"Abcam, ab34733, Texas Red ® Anti-GST antibody","description":"\u003cp\u003eSize: 500µg\u003cbr\u003e\nGoat Polyclonal GST antibody - conjugated to Texas Red®. Suitable for WB and reacts with Tag samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Goat,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nConjugation:Texas Red®,\u003cbr\u003e\nExcitation\/Emission:Ex: 589nm, Em: 615nm,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nSpecificity:Cross reactivity against Glutathione-S-Transferase from other sources may occur but has not been specifically determined.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nTexas Red™ Sulfonyl Chloride (Molecular Weight 625 daltons). Fluorochrome\/Protein Ratio: 2.0 moles Texas Red™ per mole of Goat IgG. Absorption Wavelength: 596 nm; Emission Wavelength: 620 nm.\u003cbr\u003e\nConjugation Reference: J. Titus, P. Haugland, S. Sharrow, D. Segal J. Immunol. Methods 50; 193, 1982.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification, Purification notes-This product was prepared from monospecific antiserum by immunoaffinity chromatography using GST coupled to agarose beads followed by solid phase adsorption(s) to remove any unwanted reactivities and extensive dialysis against the buffer., Storage buffer-Preservative: 0.01% Sodium azideConstituents: 1% BSA, 0.88% Sodium chloride, 0.424% Potassium phosphate solution, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nGST or Glutathione S-transferase is an enzyme family known for detoxifying endogenous and exogenous compounds through conjugation with glutathione. GSTs are about 23–28 kDa in size and are expressed in various tissues such as the liver kidneys and lungs. The GST proteins play vital roles in cellular processes and are utilized extensively in molecular biology often tagged to proteins to enhance solubility known as GST-tagged proteins.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nGST enzymes participate in critical cellular detoxification processes enhancing the solubility of toxins. As part of these processes GST enzymes do not function as part of a larger complex but are individual actors within the cell. They facilitate the conjugation reactions fundamental to cellular metabolism and detoxification making them essential for maintaining cellular health.\u003cbr\u003e\nPathways\u003cbr\u003e\nGST enzymes contribute significantly to the metabolic breakdown pathways like the xenobiotic metabolism pathway. This pathway involves proteins such as cytochrome P450 enzymes which often function upstream to modify compounds for further GST action. GSTs are important for efficiently detoxifying potentially harmful substances preventing cellular damage.\u003cbr\u003e\nGSTs have considerable relevance to cancer where their overexpression can confer drug resistance in tumor cells complicating treatment approaches. Additionally these enzymes connect with proteins such as MDR1 influencing multidrug resistance in cancer therapy. GSTs also relate to asthma where altered GST activity can affect the body's response to oxidative stress highlighting the enzyme's role in inflammatory processes.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854455001257,"sku":"ab34733","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab34733","provider":"Iright","version":"1.0","type":"link"}