{"product_id":"abcam-ab36624","title":"Abcam, ab36624, Anti-PI-9 antibody [PI9-17]","description":"\u003cp\u003eSize: 50µg\u003cbr\u003e\nMouse Monoclonal PI-9 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human SERPINB9.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Mouse,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:PI9-17,\u003cbr\u003e\nIsotype:IgG1,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Full Length Protein corresponding to Human SERPINB9.P50453,\u003cbr\u003e\nSpecificity:Ab36624 recognises Proteinase Inhibitor 9, as well as Proteinase Inhibitor 9 complexed to granzyme B. It shows no cross reactivity with other homologous serpins (PI6, PI8 and PAI2) was observed.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purity-Tissue culture supernatant, Storage buffer-pH: 7.2Preservative: 0.1% Sodium azideConstituents: 0.7% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe PI-9 protein also known as serpinB9 is a serine protease inhibitor with a molecular mass of approximately 42 kDa. It is expressed primarily in immune cells such as cytotoxic T lymphocytes and natural killer cells as well as in some neurons and hepatocytes. The protein inhibits proteolytic enzymes to prevent unwanted cell death mainly controlling granzyme B activity.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nPI-9 helps regulate immune cell activity and prevent autoimmunity by inhibiting granule-mediated apoptosis. It functions as part of a complex that manages cell death pathways acting as a guardian against excessive cytotoxic actions by the immune system. Its regulatory role ensures the balance between attacking pathogens and protecting host cells from unnecessary destruction.\u003cbr\u003e\nPathways\u003cbr\u003e\nPI-9 plays an integral role in the apoptotic pathway interacting with proteins like granzyme B to protect host cells from immune-mediated killing. It is also involved in the cellular response to stress especially within the immune system's cytotoxic responses. The protein's interaction with granzyme B highlights its role in maintaining the balance between immune defense and cellular protection.\u003cbr\u003e\nPI-9 has been linked to autoimmune conditions and cancer. It helps regulate autoimmune responses by preventing excessive apoptosis which could otherwise lead to tissue damage. In cancer PI-9 overexpression is sometimes observed potentially allowing tumor cells to evade immune surveillance. The relationship between PI-9 and granzyme B is important in understanding its dual role in disease contexts.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854503530665,"sku":"ab36624","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab36624","provider":"Iright","version":"1.0","type":"link"}