{"product_id":"abcam-ab40390","title":"Abcam, ab40390, Anti-Myelin Basic Protein antibody - Oligodendrocyte Marker","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nAnti-Myelin Basic Protein antibody (ab40390) is a rabbit polyclonal antibody detecting Myelin Basic Protein in  Western Blot . Suitable for  Mouse, Rat . - Over 270 publications - Trusted since 2008\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Rat,\u003cbr\u003e\nApplications:WB, ICCSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nAnti-Myelin Basic Protein antibody (ab40390) is a Rabbit Polyclonal antibody and is validated for use in ICC, WB in cow, human, mouse, rat samples.\u003cbr\u003e\nAnti-Myelin Basic Protein antibody (ab40390) has been cited over 272 times in peer reviewed journals and is trusted by the scientific community.\u003cbr\u003e\nAbcams high quality validation processes ensure Anti-Myelin Basic Protein antibody (ab40390) has high sensitivity and specificity.\u003cbr\u003e\nAnti-Myelin Basic Protein antibody (ab40390) has 20 independent reviews from customers.\u003cbr\u003e\nAnti-Myelin Basic Protein antibody (ab40390) specifically detects Myelin Basic Protein (UniProt ID: P04370; Molecular weight: 27kDa) and is sold in 100 ug selling sizes.\u003cbr\u003e\nMyelin Basic Protein (MBP) is a vital component of the myelin sheath, extensively studied in neuroscience. It plays a key role in maintaining myelin integrity and facilitating nerve signal transmission. Changes in MBP expression can indicate myelin damage and are relevant in various neurodegenerative conditions, including multiple sclerosis (MS) and Alzheimer's disease (AD). Studying MBP helps researchers understand myelin-related pathology and neuronal dysfunction, highlighting its importance in the broader context of neurodegenerative diseases.\u003cbr\u003e\nFor a recombinant version of Myelin Basic Protein antibody (WB, ICC\/IF, IHC-P, Human, Mouse, Rat) - see\u003cbr\u003e\nab209328\u003cbr\u003e\n- clone IGX3421.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe myelin basic protein also referred to as MBP or MBP protein plays an important mechanical role in the central nervous system. It is a major component in the formation and stability of the myelin sheath which wraps around nerve fibers to ensure efficient neural signaling. The molecular weight of MBP can vary due to alternative splicing; one common form has a mass of about 18.5 kDa. MBP is expressed predominantly in oligodendrocytes within the brain and spinal cord where it helps form the myelin sheath. MBP2 is another variant that may be mentioned in some contexts.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nMBP is not just a passive structural element; it binds and interacts with lipids and other proteins to maintain the compact structure of the myelin sheath. MBP forms part of a complex that includes various other proteins and lipids ensuring the stability and function of myelin. Misfolding or altered expression of MBP can compromise myelin integrity affecting the insulation of neural pathways and signal transmission.\u003cbr\u003e\nPathways\u003cbr\u003e\nMBP is an essential component in the pathways of myelination and neural plasticity. It plays a role in the signaling pathways that stimulate the development and maintenance of the myelin sheath. The protein interacts with other elements of the myelin sheath such as proteolipid protein (PLP) and myelin-associated glycoprotein (MAG) to coordinate its formation and repair processes.\u003cbr\u003e\nMBP is linked closely to multiple sclerosis (MS) and other demyelinating conditions. Damage to or autoimmunity against MBP leads to the degradation of the myelin sheath contributing to the neurological symptoms in MS. The protein interacts with elements of the immune system with autoantibodies targeting MBP often found in MS patients. Another disorder associated with MBP dysfunction is Charcot-Marie-Tooth disease where abnormal MBP expression and structure can impact nerve function.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46844219326633,"sku":"ab40390","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab40390","provider":"Iright","version":"1.0","type":"link"}