{"product_id":"abcam-ab40777","title":"Abcam, ab40777, Anti-IRS1+IRS2 antibody [EP263Y]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal IRS1 antibody. Suitable for IHC-P, WB, ICC\/IF, Flow Cyt (Intra) and reacts with Human, Recombinant fragment - Human samples. Cited in 30 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EP263Y,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IHC-P, ICC\/IF, Flow Cyt (Intra), WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.,\u003cbr\u003e\nSpecificity:The immunogen used for this product shares 78% homology with IRS2. Cross-reactivity with this protein has not been confirmed experimentally.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nSpecies reactivity\u003cbr\u003e\nMouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.\u003cbr\u003e\nPlease\u003cbr\u003e\ncontact us\u003cbr\u003e\nfor more information.\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe targets IRS1 and IRS2 also known as Insulin Receptor Substrate 1 and 2 are important adaptor proteins that play an important role in insulin signaling. IRS1 and IRS2 have molecular masses of approximately 180 kDa and 185 kDa respectively. These proteins are expressed in a wide range of tissues but show particularly high expression in insulin-responsive tissues such as muscle liver and adipose tissues. IRS1 and IRS2 function by interacting with activated insulin receptors allowing subsequent recruitment of downstream signaling molecules.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nIRS1 and IRS2 translate insulin receptor activation into metabolic and mitogenic effects. These proteins form signaling complexes that mediate the action of insulin and insulin-like growth factor 1 (IGF-1). IRS1 and IRS2 interact with several signaling molecules including PI3K and GRB2 which are essential for the activation of downstream pathways. Their role is essential in glucose homeostasis cell growth and differentiation. In some contexts IRS1 and IRS2 also participate in signaling pathways influenced by other growth factors.\u003cbr\u003e\nPathways\u003cbr\u003e\nIRS1 and IRS2 have pivotal roles in the insulin signaling and IGF-1 signaling pathways. They facilitate signal transduction from the insulin and IGF-1 receptors impacting both metabolic and growth-related pathways. Within these pathways their interaction with PI3K highlights their importance in glucose uptake and utilization while their connection with SHC and ERK pathways emphasizes their involvement in cell growth and proliferation. The coordinated action of IRS1 and IRS2 helps maintain energy balance and cellular functions.\u003cbr\u003e\nIRS1 and IRS2 have significant associations with type 2 diabetes and certain cancers. In type 2 diabetes alterations in IRS1 and IRS2 signaling can impair glucose metabolism leading to insulin resistance. Genetic variations or dysregulation in their function often contribute to diabetes susceptibility. Additionally IRS1 and IRS2 are linked to cancer as their pathways overlap with pathways that influence cell growth and survival. Increased signaling can enhance cell proliferation and resistance to apoptosis with relevant proteins like PI3K and AKT further involved in these processes.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850237989033,"sku":"ab40777","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab40777","provider":"Iright","version":"1.0","type":"link"}