{"product_id":"abcam-ab4385","title":"Abcam, ab4385, Anti-RPS27\/MPS1 antibody","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nGoat Polyclonal RPS27\/MPS1 antibody. Suitable for WB and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Synthetic Peptide within Human RPS27 aa 1-50.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Goat,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human RPS27 aa 1-50. The exact immunogen used to generate this antibody is proprietary information.P42677\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nOfficial Gene Symbol - RPS27. LocusLink ID - 6232 (human); 57294 (mouse); 94266 (rat). Gene Ontology terms - structural constituent of ribosome; RNA binding; zinc ion binding; protein biosynthesis; cell proliferation; signal transduction; ribosome; cytosolic small ribosomal subunit (sensu Eukarya); intracellular.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide., Storage buffer-pH: 7.3 Preservative: 0.02% Sodium azide Constituents: 0.5% BSA, 0.5% Tris, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nRPS27 also known as MPS1 is a ribosomal protein that is an essential component of the 40S subunit of the ribosome. With a molecular mass of approximately 9 kDa RPS27\/MPS1 plays a vital role in protein synthesis. This protein is expressed in multiple tissues including highly proliferative cells such as those found in the bone marrow and lymphoid tissues. Its expression level is generally correlated with cell growth and proliferation rates.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nRPS27\/MPS1 is important for ribosome assembly and function. It participates in the stabilization of ribosomal structures. This protein is often found as part of a larger ribosome complex working together with other ribosomal proteins and rRNA to ensure accurate translation of mRNA into proteins. The assembly and function of ribosomes are fundamental for cell growth and division marking RPS27\/MPS1 as significant in these processes.\u003cbr\u003e\nPathways\u003cbr\u003e\nRPS27\/MPS1 is involved in critical translation initiation and ribosomal biogenesis pathways. It interacts with proteins involved in the mTOR signaling pathway which regulates cell growth and metabolism in response to nutrients and energy status. Additionally it relates to the nucleolus stress response a pathway linked with protein synthesis and cellular stress responses. MPS1 works either directly or indirectly with proteins such as mTOR and p53 impacting cellular homeostasis and growth control mechanisms.\u003cbr\u003e\nRPS27\/MPS1 has been connected to cancer and ribosomopathies. Abnormal expressions or mutations in RPS27\/MPS1 can contribute to tumorigenesis due to its role in unchecked cell proliferation. Dysregulation of this protein is associated with breast cancer where it may interact with oncogenes and tumor suppressor genes like p53 and Bcl-2. Additionally changes in RPS27\/MPS1 expression or mutation have implications in ribosomopathies a group of diseases characterized by defective ribosome function. These connections highlight the importance of understanding RPS27\/MPS1 in disease pathogenesis.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854456180905,"sku":"ab4385","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab4385","provider":"Iright","version":"1.0","type":"link"}