{"product_id":"abcam-ab4567","title":"Abcam, ab4567, Anti-pan CEACAM antibody [D14HD11]","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nMouse Monoclonal CEAM1 antibody. Suitable for Flow Cyt, ELISA, WB, IHC-P, IHC-Fr and reacts with Human samples. Cited in 7 publications. Immunogen corresponding to Native Full Length Protein corresponding to Human CEACAM3.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Mouse,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:D14HD11,\u003cbr\u003e\nIsotype:IgG1,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IHC-Fr, IHC-P, ELISA, Flow Cyt, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Native Full Length Protein corresponding to Human CEACAM3.P40198,\u003cbr\u003e\nSpecificity:Broadly reactive with high affinity (affinity to solid phase bound CEACAM 5: 2 x 1010 L\/Mol [Jantscheff P et al.]) with most of the CEACAM molecules (except CEACAM 7 and CEACAM 8) transiently expressed on the cell surface of transfected BOSC23 cells. This antibody can be used to detect CEACAM 1 (BGP\/CD66a), CEACAM 3 (CGM1\/CD66d), CEACAM 4 (CGM 7), CEACAM 5 and CEACAM 6 (NCA\/CD66c) on transfectants by flow cytometry.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nAntibodies produced from cDNA: Conventional technologies usually either generate antibodies against purified proteins, or against synthetic peptides based on amino acid sequences derived from DNA sequence data. Genetic immunization involves introducing the gene in the form of a cDNA directly into an animal which translates this cDNA into protein thus stimulating an immune response against the foreign protein. Although the synthetic peptide approach is comparable in speed, the quality of antibodies generated by genetic immunization is far superior. This is because the protein is made by the immunized animal, utilzing complex cellular mechanisms that allow it to gain a native conformation. Antibodies are then generated against a native protein, such as is found in the blood or tissues of its host species. Membrane-bound or secreted proteins often create problems for conventional antibody technology because in their native form, they are often modified by glycosylation, or in some cases exist as multiple membrane-spanning proteins that are not soluble following isolation or synthesis in recombinant systems. All of these problems are avoided if the immunized animal makes the protein itself. Antibodies generated by genetic immunization have been shown to have binding affinities to the protein in the sub-nanomolar range, which are approximately 100x higher than conventionally developed antibodies and much higher than single chain antibodies. Results confirm published data for much higher avidity of sera generated by genetic immunization as compared with that gained by immunization with a corresponding recombinant protein.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein G, Storage buffer-Preservative: 0.01% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nPan CEACAM also known as Carcinoembryonic Antigen-related Cell Adhesion Molecule represents a group of glycoproteins. It carries a molecular weight varying between 60 to 90 kDa depending on the glycosylation extent. These molecules express mainly on epithelial cells especially those in the gastrointestinal tract and respiratory system. CEACAMs serve in cell-cell adhesion playing significant roles in maintaining tissue architecture and intercellular communication.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThese proteins participate in immunoregulation and cellular adhesion. CEACAMs function as part of larger multi-protein complexes at the cell surface interacting with numerous ligands and receptors to modulate immune responses. These proteins can inhibit or promote cellular processes such as proliferation differentiation and apoptosis. This way they help in maintaining normal cellular function and adaptation to environmental changes.\u003cbr\u003e\nPathways\u003cbr\u003e\nPan CEACAM proteins influence pathways related to cellular communication and immune response. They involve particularly in the JAK\/STAT and MAPK pathways. CEACAMs participate in initiating or modulating cascade signaling which involves proteins like STAT3 and ERK contributing to versatile cellular responses. These pathways help fine-tune cellular proliferation and survival particularly in response to external stimuli or stress.\u003cbr\u003e\nPan CEACAMs hold significant implications in cancer and inflammatory diseases. Elevated CEACAM expression associates with several types of cancer including colorectal and lung cancer where it affects tumor progression and metastasis. It also connects with inflammatory bowel disease contributing to an altered immune response and epithelial damage. In these conditions CEACAMs interact with other proteins such as CEACAM1 and CEACAM5 influencing disease development and progression.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46860471500969,"sku":"ab4567","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab4567","provider":"Iright","version":"1.0","type":"link"}