{"product_id":"abcam-ab50839","title":"Abcam, ab50839, Anti-HOXC9 antibody [HOXCA6E6]","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nMouse Monoclonal HOXC9 antibody. Suitable for WB, ICC\/IF and reacts with Human samples. Cited in 18 publications. Immunogen corresponding to Recombinant Fragment Protein within Human HOXC9.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Mouse,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:HOXCA6E6,\u003cbr\u003e\nIsotype:IgG2b,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human HOXC9. The exact immunogen used to generate this antibody is proprietary information.P31274\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein G, Purification notes-purified from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (~95%) fetal bovine serum, filtered through a 0.22µm membrane., Storage buffer-pH: 7.4Preservative: 0.05% Sodium azideConstituents: PBS, 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nHOXC9 also known as Homeobox C9 is a transcription factor that belongs to the homeobox family specifically the HOX gene cluster. It regulates gene expression by binding to specific DNA sequences. The protein has a molecular mass of about 28 kDa. HOXC9 is expressed in various tissues including the nervous system particularly during embryonic development. It plays an important role in patterning the anterior-posterior axis and the development of specific body structures.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nGenes that HOXC9 regulates play key roles in developmental processes such as neural differentiation and limb formation. HOXC9 might operate as part of a larger transcriptional complex that involves other HOX proteins allowing precise control over developmental gene expression. The protein ensures that cells at different developmental stages respond correctly to morphogenetic signals facilitating proper organismal formation.\u003cbr\u003e\nPathways\u003cbr\u003e\nHOXC9 actively participates in the retinoic acid signaling pathway important for neurodevelopmental regulation. This pathway requires a balance between HOXC9 and Receptor Interacting Protein 1 (RIP1) for correct gene expression. Another critical pathway is the Wnt signaling pathway where HOXC9 interacts with components such as beta-catenin to further modulate gene transcription related to cell fate decisions.\u003cbr\u003e\nResearch links HOXC9 dysregulation to neurodevelopmental disorders and certain cancers like leukemia. Abnormal HOXC9 expression disrupts regular neural development and contributes to malignancy. Its interaction with proteins including members of the Polycomb group like Bmi1 influences these pathologies. Understanding HOXC9's involvement helps in devising therapeutic strategies for these conditions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46855742292137,"sku":"ab50839","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab50839","provider":"Iright","version":"1.0","type":"link"}