{"product_id":"abcam-ab51252","title":"Abcam, ab51252, Anti-alpha + beta Synuclein antibody [EP1646Y]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal Alpha-synuclein antibody. Suitable for WB, ICC\/IF, Flow Cyt (Intra) and reacts with Mouse, Human, Rat samples. Cited in 28 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EP1646Y,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Rat, Human,\u003cbr\u003e\nApplications:ICC\/IF, Flow Cyt (Intra), WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nAlpha-synuclein and beta-synuclein are proteins implicated in the dynamics of neuronal function. Alpha-synuclein also known as SNCA is a synaptic protein weighing approximately 14 kDa expressed highly in the central nervous system. Unlike alpha-synuclein beta-synuclein shares a similar structure but differs in function and molecular weight. Both proteins belong to the synuclein family which also includes gamma-synuclein and are found primarily in pre-synaptic terminals contributing to synaptic vesicle physiology.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nAlpha- and beta-synuclein play roles in synaptic function and plasticity where they influence neurotransmitter release and vesicle recycling. These proteins do not generally form a stable complex with each other but their presence together suggests a regulatory interplay. Alpha-synuclein may promote vesicle formation and trafficking while beta-synuclein appears to counteract alpha's effects potentially protecting neurons from alpha-synuclein aggregation.\u003cbr\u003e\nPathways\u003cbr\u003e\nAlpha- and beta-synuclein are key components in the synaptic vesicle cycle especially associated with the SNARE complex and neurotransmitter balance. Alpha-synuclein interacts with proteins like VAMP2 and STX1A in vesicle merging while beta-synuclein's regulatory role has implications in maintaining these interactions. In lipid metabolism alpha-synuclein influences fatty acid binding protein pathways impacting neuronal lipid transport and homeostasis.\u003cbr\u003e\nAlpha- and beta-synuclein hold significant relevance particularly in neurodegenerative disorders like Parkinson's disease and dementia with Lewy bodies which show marked alpha-synuclein aggregates known as Lewy bodies. Alpha-synuclein's accumulation in neurons correlates with disease progression. Beta-synuclein on the other hand appears to have a protective role potentially mitigating the toxicity of alpha's aggregates. The relation between these synucleins underlines their importance in therapeutic research for these disorders.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46844155822249,"sku":"ab51252","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab51252","provider":"Iright","version":"1.0","type":"link"}