{"product_id":"abcam-ab51705","title":"Abcam, ab51705, Anti-GPCR GPR125 antibody","description":"\u003cp\u003eSize: 250µL\u003cbr\u003e\nRabbit Polyclonal GPCR GPR125 antibody. Suitable for ELISA, ICC\/IF and reacts with Synthetic peptide, Human samples. Cited in 19 publications. Immunogen corresponding to Synthetic Peptide within Human ADGRA3 aa 300-400 conjugated to Keyhole Limpet Haemocyanin.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:ELISA, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human ADGRA3 aa 300-400 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.Q8IWK6\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purity-Whole antiserum, Storage buffer-Constituents: Whole serum, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nG protein-coupled receptor 125 also known as GPR125 is a member of the adhesion GPCR family. It has an approximate molecular mass of 100 kDa. GPR125 is involved in signal transduction processes functioning as a receptor that spans the cell membrane. This protein is largely expressed in the testis embryonic tissues and various adult tissues including the central nervous system and heart. Its localization suggests it plays a role in complex signaling processes across development and regular adult function.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nGPR125 acts in cellular adhesion and signaling mechanisms. This receptor is not known to form part of a larger molecular complex but interacts with several cellular components to regulate biological processes. GPR125 influences cell communication and has been implicated in maintaining tissue architecture which is essential for normal cellular functions and development. Through its signaling roles GPR125 impacts cell polarity and migration.\u003cbr\u003e\nPathways\u003cbr\u003e\nGPR125 fits into cell signaling and developmental pathways. It associates with the Wnt signaling pathway which is critical for regulating cell proliferation and polarity. This receptor also displays potential links to pathways involving protein kinases related to cell adhesion and migration. Related proteins like Frizzled receptors in the Wnt pathway interact with GPR125 suggesting their collaboration in various signaling networks.\u003cbr\u003e\nMutations or dysregulation of GPR125 have connections to cancer and neurodevelopmental disorders. While its exact functional impact on specific cancers like testicular cancer remains under research GPR125's expression patterns suggest a potential role in tumor development or progression. In neurodevelopmental disorders altered GPR125 signaling could affect neural cell communication and adhesion. The protein Intelectin expressed with GPR125 in neural tissues might also contribute to understanding these conditions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46845054288041,"sku":"ab51705","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab51705","provider":"Iright","version":"1.0","type":"link"}