{"product_id":"abcam-ab5188","title":"Abcam, ab5188, Anti-CDYL antibody","description":"\u003cp\u003eSize: 50µg\u003cbr\u003e\nRabbit Polyclonal CDYL antibody. Suitable for ChIP, WB, IHC-P, ChIP-seq and reacts with Mouse, Rat, Vervet monkey, Human samples. Cited in 17 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human, African green monkey, Mouse, Rat,\u003cbr\u003e\nApplications:IHC-P, ChIP, ChIP-seq, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nCDYL known as Chromodomain Y-Like functions as a chromatin modifier protein and has molecular weight around 59 kDa. This protein features a chromodomain that enables it to bind to histone tails influencing gene expression by altering chromatin structure. CDYL expresses broadly in tissues with significant presence in the brain testis and embryonic tissue. It interacts with various protein partners to regulate multiple cellular processes ensuring proper cellular function.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe role of CDYL revolves around transcriptional repression as it integrates into chromatin-remodeling complexes. This protein contributes to the silencing of gene transcription by compacting chromatin facilitating stable epigenetic inheritance. CDYL works alongside other chromatin-associated proteins and histone deacetylases to maintain transcriptional repression. Its function in these complexes aids in establishing cell identity by regulating gene expression patterns specific to cell type and developmental stage.\u003cbr\u003e\nPathways\u003cbr\u003e\nCDYL integrates into key regulatory networks involved in epigenetic gene silencing and neuronal development. It participates in the chromatin remodeling pathway and is closely associated with the histone modification pathway impacting neuronal differentiation. CDYL interacts with proteins like HDAC1 and G9a methyltransferase coordinating the modification of histones resulting in a variety of epigenetic outcomes. These pathways ensure proper developmental processes and cellular differentiation occur in multicellular organisms.\u003cbr\u003e\nResearchers associate CDYL with conditions such as neurodevelopmental disorders and cancer. Abnormal expression or mutations in CDYL links to certain cancers including prostate cancer where it interacts with oncogenic proteins influencing cancer progression. Additionally researchers have explored its role in neurological disorders where CDYL's regulation of gene expression affects brain development and function suggesting potential involvement in disorders like schizophrenia. Understanding CDYL's interactions could offer insights into treatment strategies for these conditions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850104688809,"sku":"ab5188","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab5188","provider":"Iright","version":"1.0","type":"link"}