{"product_id":"abcam-ab52621","title":"Abcam, ab52621, Anti-RAIDD antibody [EPR1640Y]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal RAIDD antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 4 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR1640Y,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nSpecies reactivity\u003cbr\u003e\nMouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.\u003cbr\u003e\nPlease\u003cbr\u003e\ncontact us\u003cbr\u003e\nfor more information.\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nRAIDD also known as RIP-associated ICH-1\/CED-3-homologous protein with a death domain (RIPDD) is an adaptor protein with a molecular mass of approximately 22 kDa. It is important for the formation of multiprotein signaling complexes. RAIDD contains a caspase recruitment domain and a death domain which facilitate its function in apoptotic pathways. It expresses in various tissues with a significant presence in immune and neural tissues where it has roles in regulating cell death and inflammation responses.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nRAIDD interacts closely with other proteins to regulate apoptosis. It forms part of the death-inducing signaling complex (DISC) a structure that recruits and activates initiator caspases like caspase-2. By acting as a bridge between receptor-interacting protein (RIP) and caspases RAIDD transmits signals that lead to programmed cell death. This regulation is central to cellular homeostasis and responses to damaging stimuli.\u003cbr\u003e\nPathways\u003cbr\u003e\nRAIDD stands as a significant player in the apoptotic and inflammatory pathways. Apoptosis is well-documented where RAIDD serves as a connecting link to caspase-2 activation through the DISC. The second pathway of relevance is the TNF-receptor signaling pathway where RAIDD associates with RIP to influence downstream signaling events affecting expression of genes involved in immune response and cell cycle control.\u003cbr\u003e\nRAIDD's role in apoptosis and inflammation connects it to cancer and neurodegenerative diseases. In cancer RAIDD is involved in pathways that regulate tumor cell survival and death. Its interaction with proteins like caspase-2 can impact the fate of cancer cells potentially leading to abnormal cell proliferation or apoptosis resistance. In neurodegenerative conditions like Alzheimer's disease RAIDD's association with pro-inflammatory pathways and cell death mechanisms implicates it in neural cell injury and disease progression often in conjunction with RIP and caspases.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850384068777,"sku":"ab52621","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab52621","provider":"Iright","version":"1.0","type":"link"}