{"product_id":"abcam-ab53740","title":"Abcam, ab53740, Anti-RIP140 antibody [2656C6a]","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nMouse Monoclonal RIP140 antibody. Suitable for WB and reacts with Recombinant fragment - Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human Nuclear receptor-interacting protein 1.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Mouse,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:2656C6a,\u003cbr\u003e\nIsotype:IgG1,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human Nuclear receptor-interacting protein 1. The exact immunogen used to generate this antibody is proprietary information.P48552\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG depleted (approximately 95%) fetal bovine serum., Storage buffer-pH: 7.4Preservative: 0.05% Sodium azideConstituents: PBS, 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nRIP140 also known as receptor-interacting protein 140 and NRIP1 is a protein that acts as a transcriptional corepressor. It has a molecular mass of approximately 115 kDa. RIP140 is found in various tissues with high levels of expression observed in the ovary testes and adipose tissue. This protein interacts with nuclear receptors and influences gene expression by recruiting chromatin-modifying enzymes.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nRIP140 functions in regulating energy homeostasis and reproductive processes. It plays an important role in the repression of genes involved in metabolism and fat storage. RIP140 does not act alone but is part of transcriptional complexes that modulate the activity of multiple facets of gene expression. Its ability to interact with histone deacetylases and other corepressors enhances its regulatory capacity.\u003cbr\u003e\nPathways\u003cbr\u003e\nRIP140 is involved in pathways that govern glucose and lipid metabolism. It interacts notably with PPAR (peroxisome proliferator-activated receptors) and LXR (liver X receptors) both important in lipid metabolism. Energy balance influences genes that RIP140 represses or activates positioning it as a central player in metabolic regulation.\u003cbr\u003e\nRIP140's role becomes apparent in obesity and type 2 diabetes. Abnormal expression or function of RIP140 affects metabolic pathways contributing to these conditions. The protein also interacts with PGC-1α an important regulator of mitochondrial biogenesis linking it to metabolic health and disease states. Such interactions highlight the protein's significance in maintaining normal physiological balance and its potential as a therapeutic target.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854769574057,"sku":"ab53740","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab53740","provider":"Iright","version":"1.0","type":"link"}