{"product_id":"abcam-ab54100","title":"Abcam, ab54100, Recombinant Hepatitis A Virus protein","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nRecombinant Hepatitis A Virus protein is a Human hepatitis A virus Hu\/Los Angelos\/LA\/1975 Fragment protein, in the 722 to 830 aa range, expressed in Escherichia coli, with \u0026gt;90%, suitable for SDS-PAGE, ELISA, WB.\u003cbr\u003e\nKey facts\u003cbr\u003e\nPurity:\u0026gt;90% SDS-PAGE,\u003cbr\u003e\nExpression system:Escherichia coli,\u003cbr\u003e\nTags:His tag C-Terminus,\u003cbr\u003e\nApplications:WB, SDS-PAGE, ELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nBiologically active:No,\u003cbr\u003e\nAccession:P06441,\u003cbr\u003e\nAnimal free:No,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nSpecies:Human hepatitis A virus Hu\/Los Angelos\/LA\/1975,\u003cbr\u003e\nStorage buffer:pH: 9.6Constituents: 50% Glycerol (glycerin, glycerine), 9.009% Urea, 0.158% Tris HCl\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nReacts strongly with human Hepatitis A Virus positive serum.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe Hepatitis A Virus (HAV) is a small non-enveloped virus belonging to the Picornaviridae family. It possesses a single-stranded RNA genome that measures about 7.5 kilobases in length. The capsid of HAV with a mass around 27 kDa consists of proteins VP1 VP2 and VP3 which form a protective shell that facilitates the virus's stability and transmission. This virus is primarily found in the liver where it causes infection although it can also circulate in the bloodstream and be excreted in the feces.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nHAV plays a significant role in human health by causing liver inflammation. It does not form complexes with other proteins but its replication predominantly occurs in hepatocytes. Although HAV is not directly involved in forming complexes it effectively interacts with host cell machinery to produce viral proteins and new viral particles. These interactions ensure the virus thrives in a new environment by altering the cell's normal functions to favor its replication.\u003cbr\u003e\nPathways\u003cbr\u003e\nHAV significantly influences immune response and inflammation pathways. The virus triggers these pathways to counter the body's antiviral defenses leading to liver inflammation and damage. During the infection HAV interacts with host proteins such as those regulating the interferon response potentially altering their normal biological roles. These interactions can modulate the signaling further complicating the immune response and enhancing viral replication.\u003cbr\u003e\nHAV is most associated with acute hepatitis a liver disease characterized by jaundice fatigue and fever. The immune response exacerbates liver damage as the body attempts to clear the virus. Unlike some other hepatotropic viruses HAV does not cause chronic liver disease. The interaction of HAV with proteins involved in the inflammatory response such as cytokines exacerbates symptoms and impacts disease progression.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46843963113641,"sku":"ab54100","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab54100","provider":"Iright","version":"1.0","type":"link"}