{"product_id":"abcam-ab5951","title":"Abcam, ab5951, Anti-GIPC1 antibody","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nGoat Polyclonal GIPC1 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Synthetic Peptide within Human GIPC1 aa 300 to C-terminus.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Goat,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human GIPC1 aa 300 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.O14908\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide., Storage buffer-pH: 7.3Preservative: 0.02% Sodium azideConstituents: Tris buffered saline, 0.5% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe protein GIPC1 also known as GAIP-interacting protein C terminus 1 weighs approximately 36 kDa. It functions mechanically as an adaptor protein binding to PDZ domains. Expressed widely throughout tissues GIPC1 shows high expression in the brain and heart. Acting at the cellular level it plays vital roles in receptor sorting and signal transduction through interactions with various cell surface proteins.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe function of GIPC1 extends to endocytosis and cell signaling. It often forms part of protein complexes that facilitate intracellular trafficking. By interacting with membrane receptors like integrins and receptor tyrosine kinases GIPC1 aids in cell communication and adhesion processes. Its presence impacts the development and maintenance of cellular structures due to these complex formations.\u003cbr\u003e\nPathways\u003cbr\u003e\nGIPC1 participates significantly in both the Wnt signaling and Ras signaling pathways. It associates with Dishevelled proteins in the Wnt pathway contributing to modulation of cell fate and proliferation. Additionally it connects to Ras-related signaling where it interacts with receptors such as the insulin-like growth factor receptor (IGF1R) thereby mediating downstream signaling effects important for cell growth and differentiation.\u003cbr\u003e\nGIPC1 presents connections to cancer and diabetic retinopathy. In cancer aberrant GIPC1 expression influences tumor progression and metastasis by interacting with proteins like Ras and IGF1R affecting cellular proliferation and survival mechanisms. For diabetic retinopathy GIPC1 modulates angiogenic signals potentially through its partnerships with vascular endothelial growth factor receptor (VEGFR) pathways which leads to pathological neovascularization associated with vision impairment.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850146074793,"sku":"ab5951","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab5951","provider":"Iright","version":"1.0","type":"link"}