{"product_id":"abcam-ab62572","title":"Abcam, ab62572, Recombinant Human MNK1 protein","description":"\u003cp\u003eSize: 10µg\u003cbr\u003e\nRecombinant Human MNK1 protein is a Human Full Length protein, in the 2 to 465 aa range, expressed in Baculovirus infected Sf9 cells, with \u0026gt;70%, suitable for WB, FuncS.\u003cbr\u003e\nKey facts\u003cbr\u003e\nPurity:\u0026gt;70% SDS-PAGE,\u003cbr\u003e\nExpression system:Baculovirus infected Sf9 cells,\u003cbr\u003e\nTags:GST tag N-Terminus,\u003cbr\u003e\nApplications:FuncS, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nBiologically active:No,\u003cbr\u003e\nAccession:Q9BUB5,\u003cbr\u003e\nAnimal free:No,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nSpecies:Human,\u003cbr\u003e\nStorage buffer:pH: 8Constituents: 50% Glycerol (glycerin, glycerine), 0.58% Sodium chloride, 0.395% Tris HCl, 0.05% Sorbitan monolaurate, ethoxylated, 0.0462% (R*,R*)-1,4-Dimercaptobutan-2,3-diol\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nMitogen-activated protein kinase-interacting serine\/threonine-protein kinase 1 (MNK1) also known as MAP kinase-interacting kinase 1 is an enzyme with a molecular weight of approximately 51 kDa. MNK1 plays an important role in the regulation of protein synthesis by phosphorylating eukaryotic initiation factor 4E (eIF4E). Researchers find high expression of MNK1 in many tissues especially within the brain and immune system which suggests its involvement in diverse cellular processes.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe protein kinase MNK1 regulates the translation of mRNA by forming part of the signaling complex that includes eIF4E. This complex plays a role in stress response cell growth and the immune response. Protein synthesis regulated by MNK1 affects cellular activities by selectively translating specific mRNAs related to those processes. MNK1's specific regulation often depends on signals received through upstream kinases.\u003cbr\u003e\nPathways\u003cbr\u003e\nMNK1 is a part of the mitogen-activated protein kinase (MAPK) signaling cascade particularly the extracellular signal-regulated kinase (ERK) and p38 MAPK pathways. These pathways find involvement in transmitting signals from the cell membrane to the nucleus affecting gene expression and cellular responses. MNK1 modulates its activity in response to signals from upstream proteins such as ERK1\/2 or p38α\/β which are likely to influence the regulation of eIF4E and therefore translation initiation.\u003cbr\u003e\nScientists observe MNK1 implications in cancer progression and neurodegenerative diseases. MNK1-mediated phosphorylation of proteins like eIF4E and its overactivation often correlates with tumor growth and resistance to chemotherapy. Additionally research links MNK1's altered activity to neurodegenerative conditions such as Alzheimer's disease. Interactions between MNK1 and other proteins like eIF4E suggest potential roles for MNK1 in these disease pathologies making it an attractive target for therapeutic interventions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46843898560681,"sku":"ab62572","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab62572","provider":"Iright","version":"1.0","type":"link"}