{"product_id":"abcam-ab62581","title":"Abcam, ab62581, Anti-DDX3 antibody","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nRabbit Polyclonal DDX3 antibody. Suitable for ICC, WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human DDX3X.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, ICCSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human DDX3X. The exact immunogen used to generate this antibody is proprietary information.O00571,\u003cbr\u003e\nSpecificity:ab62581 detects both DDX3 and DBY.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nDDX3 also known as DEAD-box helicase 3 plays an important role mechanically as an RNA helicase involved in unwinding RNA secondary structures. The protein has a mass of approximately 73 kDa and is commonly expressed in the cytoplasm and nucleus of a wide range of cell types. Other names for DDX3 include DBX CAP-Rf and DDX3X highlighting its varied functional roles across different studies.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nDEAD-box helicase 3 serves as a multifunctional protein that regulates gene expression and is implicated in RNA splicing transport and translation. It forms part of various ribonucleoprotein complexes influencing processes such as mRNA export and translation initiation. DDX3 often interacts with other proteins like eIF4E which further modulates translation of specific mRNAs.\u003cbr\u003e\nPathways\u003cbr\u003e\nDEAD-box helicase 3 acts as an essential component in several cellular pathways. It plays roles in the Wnt\/β-catenin signaling pathway where it can influence gene transcription important for cell fate decisions. DDX3 also participates in the innate immune response pathway interacting with proteins like MAVS to modulate antiviral defense mechanisms.\u003cbr\u003e\nDEAD-box helicase 3 has been associated with various cancers including hepatocellular carcinoma and breast cancer. Abnormal DDX3 function or expression can disrupt cell cycle regulation leading to uncontrolled cell growth. Additionally in viral infections such as Hepatitis C DDX3 interacts with viral proteins to facilitate replication showcasing its role in both promoting and hindering disease progression.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46860527960233,"sku":"ab62581","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab62581","provider":"Iright","version":"1.0","type":"link"}