{"product_id":"abcam-ab63278","title":"Abcam, ab63278, Recombinant Human Neuroglobin protein","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nRecombinant Human Neuroglobin protein is a Human Full Length protein, expressed in Escherichia coli, with \u0026gt;95%, suitable for SDS-PAGE, ELISA, WB.\u003cbr\u003e\nKey facts\u003cbr\u003e\nPurity:\u0026gt;95% SDS-PAGE,\u003cbr\u003e\nExpression system:Escherichia coli,\u003cbr\u003e\nTags:Tag free,\u003cbr\u003e\nApplications:ELISA, WB, SDS-PAGESee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nBiologically active:No,\u003cbr\u003e\nAccession:Q9NPG2,\u003cbr\u003e\nAnimal free:No,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nSpecies:Human,\u003cbr\u003e\nStorage buffer:Constituents: 0.58% Sodium chloride, 0.134% PBS\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Blue Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nNeuroglobin often referred to as Ngb is a globin protein with a molecular mass of approximately 17 kDa. It is present mainly in the nervous system including the brain and retina. Ngb functions mechanically by binding oxygen and other gaseous molecules. Unlike other globins it has a hexacoordinate heme and switches between different redox states. This property allows Ngb to participate in molecular signaling and oxygen homeostasis. Neuroglobin's expression occurs in neurons glial cells and some peripheral tissues suggesting a specialized yet wide-ranging role in cellular environments.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nNeuroglobin supports cellular survival under hypoxic or oxidative stress conditions. It is not part of a larger complex but interacts independently with cellular components. Ngb can protect neural cells from apoptosis by interfering with mitochondrial pathways and caspase activation. It acts as a scavenger for reactive oxygen species reducing cellular damage. Its protective nature against neuronal injury gives it significance in maintaining cellular homeostasis and responding to metabolic stress.\u003cbr\u003e\nPathways\u003cbr\u003e\nNeuroglobin is associated with oxygen delivery and neuroprotection processes. It participates in hypoxia signaling pathways and neuroprotective pathways aiding in cell defense mechanisms. Neuroglobin's role intersects with signaling proteins such as hypoxia-inducible factor (HIF-1) contributing to the regulation of oxygen-dependent gene expression. Additionally Ngb engages with various cellular pathways to mitigate oxidative damage though its connections are typically direct rather than collaborative with other proteins.\u003cbr\u003e\nNeuroglobin connects with Alzheimer's disease and ischemic stroke both linked to oxidative stress and neuronal damage. Researchers have observed Ngb's influence in limiting neuronal apoptosis and preserving cognitive function suggesting a protective role in Alzheimer's disease. In ischemic stroke models elevated Ngb expression appears to reduce brain injury by enhancing tissue resilience under low-oxygen conditions. Additionally Ngb interactions with amyloid-beta a protein associated with Alzheimer's disease highlight its potential role in neurodegenerative research and therapy development.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46843820605609,"sku":"ab63278","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab63278","provider":"Iright","version":"1.0","type":"link"}