{"product_id":"abcam-ab64613","title":"Abcam, ab64613, Anti-Glutamine Synthetase antibody [3B6] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nAnti-Glutamine Synthetase antibody [3B6] - BSA and Azide free (ab64613) is a mouse monoclonal antibody for  Western Blot, Flow Cytometry, IHC-P, ICC\/IF, ELISA . Suitable for  Drosophila melanogaster, Human, Mouse, Rat, Zebrafish . - BSA, sodium azide, and glycerol-free for easy conjugation - Over 50 publications - Trusted since 2008\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Mouse,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:3B6,\u003cbr\u003e\nIsotype:IgG1,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Mouse, Rat, Human, Drosophila melanogaster, Zebrafish,\u003cbr\u003e\nApplications:sELISA, IHC-P, Flow Cyt, WB, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human GLUL aa 250 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.P15104\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nWhat is this antibody validated in?\u003cbr\u003e\nAnti-Glutamine Synthetase antibody [3B6] - BSA and Azide free (ab64613) is a mouse monoclonal antibody and is validated for use in Western Blot (WB), Flow Cytometry (Flow Cyt), Immunohistochemistry (IHC-P), Immunocytochemistry\/immunofluorescence (ICC\/IF), ELISA in Drosophila melanogaster, Human, Mouse, Rat, Zebrafish samples.\u003cbr\u003e\nWhat is the molecular weight of Glutamine Synthetase?\u003cbr\u003e\nAnti-Glutamine Synthetase [3B6] - BSA and Azide free (ab64613) specifically detects a band for Glutamine Synthetase (UniProt: P15104) at a molecular weight of 42kDa.\u003cbr\u003e\nTrusted by the scientific community\u003cbr\u003e\nAnti-Glutamine Synthetase [3B6] - BSA and Azide free (ab64613) was first used in a scientific publication in 2008 and has been cited over 50 times in peer-reviewed journals.\u003cbr\u003e\nReviewed by scientists\u003cbr\u003e\nAnti-Glutamine Synthetase [3B6] - BSA and Azide free (ab64613) has over 5 independent reviews from customers.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nGlutamine synthetase also known as glutamine s synthetase or glnA is an enzyme that catalyzes the ATP-dependent conversion of glutamate and ammonia into glutamine. This reaction plays an important role in nitrogen metabolism. Glutamine synthetase has a molecular weight of approximately 620 kDa and forms a multimeric structure commonly seen in bacteria plants and animal tissues with significant expression in the brain liver and kidneys.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThis enzyme supports the detoxification of ammonia by incorporating it into glutamine an essential amino acid and nitrogen donor. Glutamine synthetase operates independently rather than as part of a larger protein complex. It assists in maintaining cellular nitrogen balance and facilitates the synthesis of proteins and other nitrogen-containing molecules. Glutamine peptides serve vital roles in cellular processes underlining the significance of their synthesis.\u003cbr\u003e\nPathways\u003cbr\u003e\nGlutamine synthetase integrates into the glutamate and glutamine cycle between neurons and glial cells highlighting its part in neurotransmitter metabolism. It also features prominently in the urea cycle influencing nitrogen disposal in organisms. Glutamine synthetase interacts with glutaminase which assists in transforming glutamine back to glutamate maintaining a balance of nitrogenous compounds within these pathways.\u003cbr\u003e\nGlutamine synthetase abnormalities link to hepatic encephalopathy and neurodegenerative disorders such as Alzheimer's disease. Altered enzyme expression contributes to increased ammonia levels adversely affecting brain function. In Alzheimer's disease connections with tau and amyloid-beta proteins suggest a link between glutamine synthetase activity and neurotoxic events. Understanding these interactions may offer insights into therapeutic approaches for these conditions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46855733215401,"sku":"ab64613","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab64613","provider":"Iright","version":"1.0","type":"link"}