{"product_id":"abcam-ab64835","title":"Abcam, ab64835, Anti-LTB antibody","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nRabbit Polyclonal LTB antibody. Suitable for WB, ICC\/IF and reacts with Human samples. Cited in 7 publications. Immunogen corresponding to Synthetic Peptide within Human LTB.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human LTB. The exact immunogen used to generate this antibody is proprietary information.Q06643,\u003cbr\u003e\nSpecificity:ab64835 detects endogenous levels of total Lymphotoxin Beta protein.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nLTB also known as Lymphotoxin Beta is a member of the TNF (tumor necrosis factor) superfamily. Its molecular weight is approximately 33 kDa. LTB is expressed mainly in lymphoid tissues particularly in the spleen and thymus. This protein exists as a membrane-bound homotrimer or heterotrimer with Lymphotoxin Alpha influencing cellular processes both as individual units and in complex structures.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nLTB contributes to the formation and maintenance of secondary lymphoid tissues. LTB forms a complex with Lymphotoxin Alpha in a heterotrimeric arrangement which links it to immune responses by managing lymphoid organogenesis. It participates in regulating inflammation and maintaining organized lymphoid architecture impacting germinal center formation in response to antigenic stimulation.\u003cbr\u003e\nPathways\u003cbr\u003e\nLTB plays a significant role in the NF-kB signaling pathway and lymphoid tissue organization. It interacts with the NF-kB pathway by engaging lymphotoxin-beta receptor (LTBR) leading to the activation of transcription factors. This interaction is vital in ensuring the proper migration and positioning of leukocytes associating LTB closely with proteins like LTBR and Rel proteins.\u003cbr\u003e\nLTB demonstrates a significant link to autoimmune diseases and lymphomas. Its overexpression can contribute to chronic inflammatory conditions and certain types of B-cell lymphomas often through dysregulation of the NF-kB signaling pathway. In these conditions LTB interacts closely with associated molecules like LTBR and potentially with other TNF family members indicating its influence in pathological inflammatory pathways.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854128664745,"sku":"ab64835","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab64835","provider":"Iright","version":"1.0","type":"link"}