{"product_id":"abcam-ab64937","title":"Abcam, ab64937, Anti-ELF1 antibody","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nRabbit Polyclonal ELF1 antibody. Suitable for WB, ICC\/IF and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human ELF1.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:ICC\/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human ELF1. The exact immunogen used to generate this antibody is proprietary information.P32519\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe ELF1 (E74 Like ETS Transcription Factor 1) protein serves as a transcription factor involved in regulating gene expression. It is also known as E74-like factor 1 or ELF-1. This protein has a molecular mass of approximately 68 kDa and is expressed in various tissues with high levels observed in the thymus and peripheral blood leukocytes. ELF1 plays a role in activating or repressing specific genes by binding to DNA sequences in their promoter regions. This transcriptional activity influences cell growth differentiation and other vital cellular processes.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nELF1 plays an important role in immune cell function and development. It operates as part of the ETS family of transcription factors which form complexes with other proteins to exert their effects on gene expression. ELF1 contributes to the regulation of T-cell development and function an essential process in maintaining efficient immune responses. The protein also influences other cellular processes including hematopoiesis and lymphoid organogenesis due to its target genes.\u003cbr\u003e\nPathways\u003cbr\u003e\nELF1 participates in immune system pathways including those governing T-cell activation and differentiation. These pathways often involve synergy with related proteins such as ELK1 and ETS1 which also belong to the ETS transcription factor family. These proteins exhibit interactions that modulate cellular responses during immune signaling. ELF1's regulatory influence helps maintain balance between proliferation and differentiation critical for immune system function.\u003cbr\u003e\nELF1 has links to certain autoimmune diseases like systemic lupus erythematosus (SLE) and hematological malignancies such as leukemia. Abnormal ELF1 expression or function may disrupt normal immune regulation contributing to autoimmune pathology. Moreover interactions with proteins like PAX5 in lymphoid cells can relate to oncogenic processes. Here ELF1's regulation can become dysregulated aiding in cancer progression or the onset of autoimmune conditions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854040682665,"sku":"ab64937","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab64937","provider":"Iright","version":"1.0","type":"link"}