{"product_id":"abcam-ab6513","title":"Abcam, ab6513, Anti-HSV1 ICP0 antibody [5H7]","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nMouse Monoclonal ICP0 antibody. Suitable for ICC\/IF, WB, ELISA and reacts with Herpes simplex virus samples. Cited in 54 publications. Immunogen corresponding to Virus preparation containing HSV1 ICP0 protein.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Mouse,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:5H7,\u003cbr\u003e\nIsotype:IgG1,\u003cbr\u003e\nLight chain type:kappa,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Herpes simplex virus,\u003cbr\u003e\nApplications:ELISA, WB, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nHSV1 ICP0 also known as Herpes Simplex Virus type 1 Infected Cell Protein 0 is a multifunctional viral protein expressed during infection with HSV1. It has a molecular mass of approximately 110 kDa. ICP0 acts as an E3 ubiquitin ligase targeting cellular proteins for ubiquitination and subsequent proteasomal degradation. This helps the virus evade the host's antiviral defenses. HSV1 ICP0 is expressed in the nuclei of infected cells and facilitates the viral lytic replication cycle enabling the virus to reactivate from latency.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe protein HSV1 ICP0 dismantles host cellular defenses by disrupting PML nuclear bodies which are involved in the intrinsic immune response. ICP0 does not operate alone as it is part of a larger regulatory complex that modulates the expression of viral and host genes. By interacting with key host factors ICP0 enhances the efficiency of viral replication ensuring the successful propagation of HSV1 in the host.\u003cbr\u003e\nPathways\u003cbr\u003e\nICP0 influences both immune evasion and viral replication pathways through its interactions with host proteins. It plays a role in the host's ubiquitin-proteasome system and interferes with the DNA damage response pathway. Interactions with proteins like ubiquitin-specific protease 7 (USP7) and the ubiquitin ligase RNF8 illustrate ICP0's multifunctional role in manipulating host-cell pathways to favor viral replication.\u003cbr\u003e\nHSV1 ICP0 plays a significant role in herpes simplex virus infections. It contributes to the reactivation of latent infections leading to diseases such as herpes labialis (cold sores) and even more serious conditions like encephalitis. ICP0 interacts with cellular proteins involved in neuroinflammation such as NF-kB impacting the progression of these diseases. Understanding the role of ICP0 in these processes provides essential insights for developing therapeutic strategies targeting HSV1 and related conditions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46855693172905,"sku":"ab6513","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab6513","provider":"Iright","version":"1.0","type":"link"}