{"product_id":"abcam-ab65152","title":"Abcam, ab65152, Anti-IEX1\/IER3 antibody","description":"\u003cp\u003eSize: 50µg\u003cbr\u003e\nRabbit Polyclonal IEX1\/IER3 antibody. Suitable for WB, IHC-P, ICC\/IF and reacts with Human, Mouse samples. Cited in 7 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human, Mouse,\u003cbr\u003e\nApplications:WB, IHC-P, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe protein Immediate Early Response 3 (IER3) also known as IEX1 is an early-response gene product with a mass of approximately 19 kDa. It expresses in various tissues including the skin liver and immune system cells notably in T lymphocytes. IER3 regulates cellular processes such as growth and differentiation by influencing cellular apoptosis and survival mechanisms.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nImmediate Early Response 3 plays a significant role in cellular stress response and immune signaling. IER3 does not form a traditional complex but interacts with intracellular signaling molecules to modulate apoptosis. It also influences the activity of MAPK and NF-kB pathways critical for stress response and inflammation. Through this modulation IER3 directly impacts cell fate under stress conditions.\u003cbr\u003e\nPathways\u003cbr\u003e\nImmediate Early Response 3 is involved in modulating cellular survival and stress response pathways. It interacts with the MAPK signaling pathway which regulates cell growth division and stress response. IER3 influences pathways involving NF-kB a protein complex controlling transcription of DNA and cytokine production. These pathways connect IER3 to other proteins such as Bcl-2 and caspases modifying cellular responses.\u003cbr\u003e\nImmediate Early Response 3 associates with cancer progression and autoimmune diseases. Its expression levels can influence the development of certain cancers by altering apoptosis and cell proliferation rates. In autoimmune disorders IER3 affects immune responses being linked to proteins like NF-kB which regulates inflammation. Understanding the role of IER3 could aid in developing therapies for conditions like rheumatoid arthritis or certain cancer types.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854096978089,"sku":"ab65152","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab65152","provider":"Iright","version":"1.0","type":"link"}