{"product_id":"abcam-ab67728","title":"Abcam, ab67728, Anti-HESX1 antibody","description":"\u003cp\u003eSize: 50µg\u003cbr\u003e\nMouse Polyclonal HESX1 antibody. Carrier free. Suitable for WB and reacts with Transfected cell lysate - Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human HESX1.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Mouse,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Full Length Protein corresponding to Human HESX1.Q9UBX0\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nHESX1 also known as Homeobox expressed in ES cells 1 is a homeobox gene encoding a protein with a molecular mass of approximately 22 kDa. This protein acts as a transcriptional repressor and is expressed in the early stages of embryonic development particularly within the anterior pituitary gland and developing forebrain. The HESX1 protein interacts with DNA sequences to regulate the expression of target genes essential for forebrain and pituitary formation.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nHESX1 functions as a transcriptional repressor influencing the development of head and pituitary embryogenesis. This protein is not part of a larger complex but works by binding directly to promoter regions of DNA affecting transcriptional activity. HESX1 plays a critical role in regulating the expression of genes necessary for early development and cellular differentiation ensuring proper formation of the forebrain and pituitary gland.\u003cbr\u003e\nPathways\u003cbr\u003e\nHESX1 is involved in important developmental pathways including the Wnt signaling and Sonic Hedgehog pathways. These pathways govern cellular processes such as proliferation differentiation and morphogenesis. HESX1's role in these pathways connects it with proteins like β-catenin in the Wnt signaling and SHH protein in the Sonic Hedgehog pathway which are essential for maintaining the balance of cell growth and organ development.\u003cbr\u003e\nMutations in HESX1 are associated with septo-optic dysplasia and combined pituitary hormone deficiency. These conditions affect brain and pituitary development leading to clinical manifestations like optic nerve hypoplasia and hormone deficiencies. The connection of HESX1 with proteins like LHX3 in these disorders highlights its influential role in developmental regulation and disease manifestation.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46852276420777,"sku":"ab67728","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab67728","provider":"Iright","version":"1.0","type":"link"}