{"product_id":"abcam-ab68067","title":"Abcam, ab68067, Anti-FBXO31 antibody","description":"\u003cp\u003eSize: 50µg\u003cbr\u003e\nMouse Polyclonal FBXO31 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human FBXO31.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Mouse,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Full Length Protein corresponding to Human FBXO31.Q5XUX0\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nFBXO31 also known as F-box only protein 31 functions as part of the SCF (SKP1-Cullin-F-box) E3 ubiquitin protein ligase complex. It plays a role in marking proteins for proteasomal degradation. The molecular weight of FBXO31 is approximately 73 kDa. Gene expression analysis shows FBXO31 is present in various tissues with notable levels in the brain liver and kidney.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nFBXO31 regulates cell cycle progression and stress response pathways. It forms part of the SCF complex facilitating ubiquitination by recognizing and binding specific substrates. The protein contributes to the regulation of cell cycle checkpoints and is involved in DNA repair processes. This makes FBXO31 important for maintaining genomic stability during cell division and protecting against cellular stress.\u003cbr\u003e\nPathways\u003cbr\u003e\nFBXO31 interacts with mechanisms like the p53 signaling pathway and the ubiquitin-dependent proteolysis pathway. In the p53 signaling pathway FBXO31 targets specific proteins that modulate p53 activity affecting cell cycle arrest and apoptosis. Additionally FBXO31 links to other proteins such as SKP1 and Cullin which are essential components of the SCF complex and participate in substrate ubiquitination.\u003cbr\u003e\nFBXO31 has associations with cancer particularly breast and liver cancers. FBXO31 levels can influence tumor suppressor functions linking it to the pathogenesis of these cancers. Researchers have observed connections between FBXO31 and p53 mutations which further implicate its role in tumor development and progression. Understanding these associations highlights the potential of FBXO31 as a target for therapeutic strategies in oncology.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850144665769,"sku":"ab68067","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab68067","provider":"Iright","version":"1.0","type":"link"}