{"product_id":"abcam-ab68889","title":"Abcam, ab68889, Anti-GCET1 antibody [RAM341]","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nAnti-GCET1 antibody [RAM341] (ab68889) is a mouse monoclonal antibody detecting GCET1 in  IHC-P . Suitable for  Human . - Over 10 publications - Trusted since 2008\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Mouse,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:RAM341,\u003cbr\u003e\nIsotype:IgG1,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nWhat is this antibody validated in?\u003cbr\u003e\nAnti-GCET1 antibody [RAM341] (ab68889) is a mouse monoclonal antibody and is validated for use in Immunohistochemistry (IHC-P) in Human samples.\u003cbr\u003e\nTrusted by the scientific community\u003cbr\u003e\nAnti-GCET1 [RAM341] (ab68889) was first used in a scientific publication in 2008 and has been cited over 10 times in peer-reviewed journals.\u003cbr\u003e\nWant a custom formulation?\u003cbr\u003e\nThis antibody clone is manufactured by Abcam. If you require a custom buffer formulation or conjugation for your experiments, please contact orders@abcam.com\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification, Purification notes-This antibody was purified using a AKTA prime., Storage buffer-Preservative: 0.02% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nGCET1 or germinal center B-cell expressed transcript 1 is a protein also known as CLL-1. It weighs approximately 43 kDa. This protein primarily appears in germinal center B-cells and shows up in some cases of diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma. It usually marks the cells involved in proliferation processes which are critical in some lymphomas’ pathogenesis and progression.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nGCET1 participates in the regulation of B-cell proliferation and survival although it is not itself a signaling molecule. It operates mainly within the immune system particularly affecting B-cells. This protein does not typically form part of a larger complex but may influence the activity of other proteins tied to B-cell activation and development aiding in the control of immune responses.\u003cbr\u003e\nPathways\u003cbr\u003e\nGCET1 shows involvement with B-cell receptor signaling and associated signaling pathways. These pathways are central to lymphocyte development activation and differentiation. It interacts closely with essential signaling proteins like SYK and BLNK. Alterations in these pathways can contribute to improper B-cell functioning and linked immunological abnormalities.\u003cbr\u003e\nGCET1 often relates to lymphoma particularly diffuse large B-cell lymphoma and follicular lymphoma. The protein GCET1 shows reciprocal connections with other molecules like BCL-6 in these cancers. Understanding GCET1 helps in identifying potential therapeutic targets and aids in diagnosing certain lymphoid malignancies underlining its value in clinical research related to these conditions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854737723561,"sku":"ab68889","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab68889","provider":"Iright","version":"1.0","type":"link"}