{"product_id":"abcam-ab69066","title":"Abcam, ab69066, Anti-ST6GalNAc I antibody","description":"\u003cp\u003eSize: 50µg\u003cbr\u003e\nMouse Polyclonal ST6GalNAc I antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human ST6GALNAC1.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Mouse,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Full Length Protein corresponding to Human ST6GALNAC1.Q9NSC7\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nST6GalNAc I also known as ST6 N-acetylgalactosaminide alpha-26-sialyltransferase 1 plays an important mechanical role in glycosylation processes. It adds sialic acid to the terminal position of N-acetylgalactosamine on glycoproteins. The enzyme has a molecular weight of around 55 kDa. Expression of ST6GalNAc I is found predominantly in the Golgi apparatus where glycosylation occurs. It is expressed in tissues such as the liver heart and brain though expression levels can vary.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nST6GalNAc I is involved in the regulation of cell-to-cell interactions and immune responses. It is not known to be a part of larger enzyme complexes but operates independently adding sialic acid residues that can modify the properties and functions of glycoproteins on the cell surface. These modifications can influence cell signaling migration and adhesion through their effects on the cell glycocalyx.\u003cbr\u003e\nPathways\u003cbr\u003e\nST6GalNAc I plays a role in the sialylation pathway which affects processes like cellular communication and protein stability. The enzyme's activity influences the O-glycan biosynthesis pathway. It works alongside other proteins such as ST3Gal I and ST6Gal I to fine-tune the sialylation states of glycoconjugates. This tuning can significantly impact interactions at the cell surface therefore influencing downstream signaling events.\u003cbr\u003e\nST6GalNAc I has a link to cancer and autoimmune disorders. Abnormal expression or activity of ST6GalNAc I can alter glycosylation patterns contributing to the progression of colon cancer by influencing tumor cell metastasis and immune cell evasion. Changes in its activity also have associations with autoimmune conditions where they may disrupt normal immune cell recognition and response. The target's modulation affects other proteins like MUC1 often implicated in cancer and immune-related anomalies.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850116780201,"sku":"ab69066","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab69066","provider":"Iright","version":"1.0","type":"link"}