{"product_id":"abcam-ab6982","title":"Abcam, ab6982, Anti-Adenovirus Type 5 antibody","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nAnti-Adenovirus Type 5 antibody (ab6982) is a rabbit polyclonal antibody detecting Adenovirus Type 5 in  Western Blot, ICC\/IF, ELISA, Neut . Suitable for  Human adenovirus 5 . - Over 80 publications - Trusted since 2001\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human adenovirus 5,\u003cbr\u003e\nApplications:ICC\/IF, ELISA, WB, FuncS (Neut\/Block)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nProduct Specifications\u003cbr\u003e\nAnti-Adenovirus Type 5 antibody (ab6982) is a rabbit polyclonal antibody and is validated for use in ELISA, ICC\/IF, Neut, WB in human adenovirus 5 samples.\u003cbr\u003e\nAnti-Adenovirus Type 5 antibody (ab6982) specifically detects Adenovirus Type 5 (UniProt ID: ; Molecular weight: kDa) and is sold in 100 µL and 1 mL selling sizes.\u003cbr\u003e\nQuality and Validation\u003cbr\u003e\nAbcam's high quality validation processes ensure Anti-Adenovirus Type 5 antibody (ab6982) has high sensitivity and specificity.\u003cbr\u003e\nAnti-Adenovirus Type 5 antibody (ab6982) has been cited over 85 times in peer reviewed journals and is trusted by the scientific community.\u003cbr\u003e\nAnti-Adenovirus Type 5 antibody (ab6982) has 9 independent reviews from customers.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purity-Whole antiserum, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nAdenovirus Type 5 also known as Ad5 is a non-enveloped virus with a double-stranded DNA genome. It is a member of the adenoviridae family which exhibits an icosahedral capsid structure and an approximate mass of 150 MDa. Adenoviruses including Type 5 target various human tissues predominantly the epithelial cells in the respiratory gastrointestinal and urinary tracts. They utilize CAR (Coxsackie and Adenovirus Receptor) for cell entry showcasing their specific interaction with host cells.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nAdenoviruses like Type 5 are associated with several intracellular processes and response mechanisms. Typically they are not part of a larger biological complex but interact dynamically with the host cell machinery. During the infection process Ad5 manipulates host replication and transcription pathways to facilitate its own replication subverting normal cellular controls. This action often results in the inhibition of host cell DNA synthesis while encouraging viral replication.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe adenovirus Type 5 engages significantly with the cellular pathways regulating apoptosis and immune response modulation. It interacts with p53 and E1A proteins which are essential influencers of cell cycle control and apoptosis. Through these interactions Ad5 can modulate the host's apoptotic pathways ensuring the virus can replicate efficiently while evading immune surveillance and promoting viral persistence.\u003cbr\u003e\nAdenovirus Type 5 is most notably linked to respiratory illnesses and conjunctivitis. In respiratory infections Ad5 exploits the immune modulation pathways resulting in inflammation and symptoms of the common cold. It can associate with other proteins like the E3 region proteins helping evade host immune responses and leading to prolonged infection or more severe symptoms. In the context of ocular infections such as conjunctivitis similar mechanisms apply whereby the adenovirus disregards normal immune clearance perpetuating the infection cycle.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46855753334953,"sku":"ab6982","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab6982","provider":"Iright","version":"1.0","type":"link"}