{"product_id":"abcam-ab70156","title":"Abcam, ab70156, Anti-B3GNT3 antibody","description":"\u003cp\u003eSize: 50µg\u003cbr\u003e\nMouse Polyclonal B3GNT3 antibody. Carrier free. Suitable for WB and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human B3GNT3.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Mouse,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Full Length Protein corresponding to Human B3GNT3.Q9Y2A9\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein G, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nB3GNT3 also known as beta-13-N-acetylglucosaminyltransferase 3 plays a role in the synthesis of poly-N-acetyllactosamine chains. The target protein with a mass of approximately 40 kDa transfers N-acetylglucosamine from UDP-GlcNAc to a beta-galactoside link forming beta-13 linkage. B3GNT3 is important for the assembly of carbohydrate structures on cell surfaces. It is widely expressed in human tissues such as the lungs stomach and various epithelial cells where glycosylation is essential for cellular interaction and communication.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nB3GNT3 functions in the modification of glycoproteins and glycolipids affecting cellular adhesion and signaling processes. As a part of the larger glycosylation enzyme complex this enzyme influences the maturation of proteins through the addition of carbohydrate chains. The expression levels of B3GNT3 directly impact the stability and function of glycoconjugates which play roles in immune responses and cell-cell recognition.\u003cbr\u003e\nPathways\u003cbr\u003e\nCellular glycosylation processes heavily depend on B3GNT3 activity within the biosynthesis of poly-N-acetyllactosamine structures. This protein operates in the glycan metabolism pathway influencing the structure of glycans on glycoproteins and glycolipids. Through its interactions with other glycosyltransferases B3GNT3 affects cell signaling pathways including immune cell regulation and inflammation responses. The protein collaborates closely with other enzymes like B3GNT2 and B4GALT1 which also participate in glycan synthesis maintaining cellular homeostasis.\u003cbr\u003e\nDisruptions in B3GNT3 activity lead to abnormalities in glycosylation patterns which relate to disorders such as cancer metastasis and congenital disorders of glycosylation. Altered B3GNT3 function affects cell adhesion properties contributing to cancer cell spread. Additionally it connects to immunological disorders through its influence on glycoprotein structures impacting immune recognition and response. B3GNT3's dysregulation pairs with proteins such as CD44 in cancer influencing the metastatic potential of tumor cells.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850107834537,"sku":"ab70156","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab70156","provider":"Iright","version":"1.0","type":"link"}