{"product_id":"abcam-ab72054","title":"Abcam, ab72054, Anti-MKRN1 antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal MKRN1 antibody. Suitable for IP, WB and reacts with Human, Mouse samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human MKRN1.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Human,\u003cbr\u003e\nApplications:WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human MKRN1. The exact immunogen used to generate this antibody is proprietary information.Q9UHC7\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: PBS, 1.815% Tris, 1.764% Sodium citrate, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nMKRN1 also known as Makorin-1 is a protein that functions as an E3 ubiquitin ligase. This protein has a molecular mass of approximately 58-60 kDa. It is highly expressed in human tissues including the brain heart and skeletal muscle. MKRN1 contains distinct zinc finger motifs that allow it to tether to its substrates aiding in target protein modification and degradation.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nMKRN1 regulates protein stability and turnover within cells. It plays a significant role in controlling gene expression through ubiquitination processes. MKRN1 does not form part of larger protein complexes but interacts individually with its targets. Researchers study its impact on the transcriptional activities of specific proteins given its ability to tag substrates for proteasomal degradation.\u003cbr\u003e\nPathways\u003cbr\u003e\nMKRN1 participates in key cellular pathways such as cell cycle regulation and apoptosis. It interacts with proteins like p53 and ribosomal protein L6 influencing these pathways. Its ubiquitin ligase function connects it to various cellular control mechanisms essential for maintaining homeostasis and responding to cellular stressors.\u003cbr\u003e\nResearchers established a connection between MKRN1 and cancer specifically prostate cancer. Its regulation of p53 activity influences tumor growth and cell death. Additionally studies show links between MKRN1 and neurodegenerative disorders implicating its role in protein aggregation and neuron survival. MKRN1's interaction with key proteins such as p53 and neuronal factors highlights its potential as a therapeutic target in these diseases.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46853935268009,"sku":"ab72054","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab72054","provider":"Iright","version":"1.0","type":"link"}