{"product_id":"abcam-ab72179","title":"Abcam, ab72179, Anti-TRH-R antibody","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nRabbit Polyclonal TRH-R antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Synthetic Peptide within Human Thyrotropin-releasing hormone receptor aa 350 to C-terminus.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human Thyrotropin-releasing hormone receptor aa 350 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.P34981\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein G, Storage buffer-pH: 7.4Preservative: 0.05% Sodium azideConstituents: PBS, 0.2% Gelatin, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nTRH-R also known as Thyrotropin-Releasing Hormone Receptor is a G-protein-coupled receptor specifically binding the tripeptide hormone TRH. This receptor has a molecular weight of approximately 70 kDa. It is express in high levels in the anterior pituitary gland as well as the central nervous system and various peripheral tissues. TRH-R plays a mechanical role in mediating the effects of TRH which include stimulating the release of thyroid-stimulating hormone (TSH) and prolactin from the anterior pituitary.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe TRH-R is involved in important physiological processes. The binding of TRH to TRH-R initiates a cascade of intracellular events leading to the activation of phospholipase C and the subsequent production of inositol triphosphate and diacylglycerol. This signaling pathway elevates intracellular calcium levels and ultimately modulates the secretion of hormones like TSH. TRH-R does not form part of a larger complex but relies on interaction with heterotrimeric G proteins to exert its effects.\u003cbr\u003e\nPathways\u003cbr\u003e\nTRH-R is significantly involved in the hypothalamic-pituitary-thyroid axis. Upon activation by TRH TRH-R activates signaling pathways that regulate thyroid hormone levels playing a role in metabolism. It also interacts with other receptors such as somatostatin receptors which can modulate the inhibitory effects on hormone secretion processes.\u003cbr\u003e\nThe dysregulation of TRH-R function has links with conditions like hypothyroidism and hyperprolactinemia. In these disorders the altered signaling of TRH-R influences the levels of important hormones such as TSH and prolactin. TRH-R connects with thyrotropin and prolactin-related proteins which serves as both diagnostic markers and potential therapeutic targets in these diseases.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850095710377,"sku":"ab72179","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab72179","provider":"Iright","version":"1.0","type":"link"}