{"product_id":"abcam-ab72368","title":"Abcam, ab72368, Anti-Elongation factor 1-gamma antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal Elongation factor 1-gamma antibody. Suitable for IHC-P, ICC\/IF, IP, WB and reacts with Human, Mouse samples. Cited in 7 publications. Immunogen corresponding to Synthetic Peptide within Human EEF1G aa 200-250.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Human,\u003cbr\u003e\nApplications:ICC\/IF, IP, WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human EEF1G aa 200-250. The exact immunogen used to generate this antibody is proprietary information.P26641\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 6.8 - 7.4Preservative: 0.09% Sodium azideConstituents: Tris buffered saline, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nElongation factor 1-gamma sometimes called EF-1γ is a protein that plays an important role in the process of protein biosynthesis. It is part of the elongation factor complex essential for the elongation phase of translation. This protein has a molecular weight of about 50 kDa. EF-1γ is expressed ubiquitously meaning it is found in many different types of tissues throughout the body indicating its broad necessity for cellular function.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nElongation factor 1-gamma supports the stability and functionality of the larger elongation factor 1 complex which also includes EF-1 alpha EF-1 beta and EF-1 delta. This complex facilitates the economic and rapid engagement of aminoacyl-tRNA to the ribosome's A-site which is important in the synthesis of proteins ensuring that proteins are accurately and efficiently elongated during translation.\u003cbr\u003e\nPathways\u003cbr\u003e\nElongation factor 1-gamma has significance in the translation pathway and is also linked to the mTOR signaling pathway. The translation pathway is fundamental for general protein synthesis while the mTOR pathway is pivotal in regulating cell growth and proliferation. In these contexts elongation factor 1-gamma associates with other proteins such as elongation factor 1 alpha to optimize the elongation step of protein synthesis impacting cell growth and survival.\u003cbr\u003e\nElongation factor 1-gamma shows connections to certain cancer types and neurodegenerative diseases. In cancer alterations or dysregulations of EF-1γ expression can influence tumor growth and development. Meanwhile relation to neurodegenerative disorders is under study as EF-1γ participates in protein synthesis with possible impacts on neuronal survival. Elongation factor 1-gamma’s interactions with proteins like EF-1 alpha in these conditions spotlight its importance to cellular homeostasis and pathology.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46855805730985,"sku":"ab72368","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab72368","provider":"Iright","version":"1.0","type":"link"}