{"product_id":"abcam-ab72487","title":"Abcam, ab72487, Anti-MHC Qa1b antibody [6A8.6F10.1A6]","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nMouse Monoclonal HA15 antibody. Suitable for WB, Flow Cyt and reacts with Mouse samples. Cited in 2 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Mouse,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:6A8.6F10.1A6,\u003cbr\u003e\nIsotype:IgG1,\u003cbr\u003e\nLight chain type:kappa,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse,\u003cbr\u003e\nApplications:Flow Cyt, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab72487 can be used for flow cytometric assay to detect Qa1b on immuno-regulatory antigen presenting cells and activated splenic T cells on Qa1b expressing mice (e.g. BALB\/c, C57BL\/6) and it can also be used for functional assays to block target cell recognition by CTLs specific for Qa1 restricted antigen presentation and other functional study where Qa1b associated immuno-regulation may work.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein G, Storage buffer-pH: 7.4Preservative: 0.05% Sodium azideConstituents: PBS, 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nMHC Qa1b also known as Qa-1b is a non-classical MHC class Ib molecule. It weighs approximately 45 kDa and belongs to the MHC class I family. Qa-1b is mainly expressed on the surface of lymphocytes as well as other nucleated cells. Its primary function includes the presentation of peptide antigens to CD8+ T cells facilitating immune surveillance. Qa-1b molecules possess a restricted tissue distribution compared to classical MHC molecules which makes them unique in their function and expression.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nQa-1b plays an essential role in modulating immune responses. It interacts as a ligand with CD94\/NKG2 receptors on natural killer (NK) cells and some T cells impacting the regulation of these cells’ activity. Through this interaction Qa-1b contributes to the inhibition or activation of NK cells influencing immune tolerance and the immune system’s response to infected or transformed cells. Qa-1b as part of a larger complex associates with β2-microglobulin to form a stable structure on the cell surface essential for its antigen-presenting function.\u003cbr\u003e\nPathways\u003cbr\u003e\nQa-1b contributes significantly to both the innate and adaptive immune pathways. By acting within the antigen presentation and NK cell activity pathways Qa-1b cooperates with other molecules involved in immune regulation such as MHC class I molecules and immunoreceptors like CD94\/NKG2. This collaboration ensures proper immune system function by maintaining balance between immune surveillance and self-tolerance preventing autoimmunity.\u003cbr\u003e\nQa-1b has a potential connection to autoimmune diseases and cancer. Its role in maintaining immune tolerance makes it a critical factor in conditions like rheumatoid arthritis where immune regulation is disrupted. Qa-1b's interaction with CD94\/NKG2 receptors can also influence tumor immunity as it might help cancer cells evade immune detection. Understanding Qa-1b’s function and interactions with other proteins in these contexts is important for developing therapeutic approaches targeting these diseases.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854686539945,"sku":"ab72487","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab72487","provider":"Iright","version":"1.0","type":"link"}