{"product_id":"abcam-ab72591","title":"Abcam, ab72591, Anti-HOXA11 antibody","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nRabbit Polyclonal HOXA11 antibody. Suitable for WB, ICC\/IF and reacts with Mouse, Human samples. Cited in 6 publications. Immunogen corresponding to Synthetic Peptide within Human HOXA11.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Human,\u003cbr\u003e\nApplications:WB, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human HOXA11. The exact immunogen used to generate this antibody is proprietary information.P31270\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nHOXA11 also known as homeobox A11 is a transcription factor involved in the regulation of gene expression. It belongs to the homeobox family and consists of about 33 kilodaltons. This target is expressed in various tissues including the uterus kidney and some parts of the nervous system. HOXA11 plays a significant role in the developmental process and cellular differentiation by binding to DNA sequences and influencing the transcriptional output of specific genes.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nHOXA11 is essential in limb and organ development such as kidneys and the female reproductive tract. As part of the regulatory gene family it interacts with other transcription factors and proteins forming complexes that are pivotal for developmental processes. HOXA11 contributes to the patterning of embryonic territories by specifying the identity and spatial arrangement of segments along the body axes. This transcription factor's activity highlights its importance in normal physiological development.\u003cbr\u003e\nPathways\u003cbr\u003e\nHOXA11 functions are integral to the Wnt signaling pathway and the retinoic acid pathway. In these pathways HOXA11 can interact with proteins like Wnt which influences cellular processes such as proliferation differentiation and migration. The transcriptional regulation associated with HOXA11 is important for proper signaling within these pathways thereby impacting various developmental stages and processes.\u003cbr\u003e\nHOXA11 has implications in congenital malformations and reproductive disorders. Mutations in HOXA11 may result in the malformation of limbs or conditions such as Mayer-Rokitansky-Küster-Hauser syndrome owing to its role in reproductive tract development. Additionally interactions with proteins like Wnt are also relevant since these interactions might contribute to the pathogenesis of developmental disorders highlighting the clinical significance of understanding HOXA11 function and regulation.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854140231849,"sku":"ab72591","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab72591","provider":"Iright","version":"1.0","type":"link"}