{"product_id":"abcam-ab74571","title":"Abcam, ab74571, Recombinant Polyomavirus strain RA Major Capsid VP1 protein","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nRecombinant Polyomavirus strain RA Major Capsid VP1 protein is a Murine polyomavirus strain A2 Full Length protein, expressed in Saccharomyces cerevisiae , with \u0026gt;75%, suitable for ELISA, WB, SDS-PAGE.\u003cbr\u003e\nKey facts\u003cbr\u003e\nPurity:\u0026gt;75% SDS-PAGE,\u003cbr\u003e\nExpression system:Saccharomyces cerevisiae,\u003cbr\u003e\nTags:Tag free,\u003cbr\u003e\nApplications:ELISA, WB, SDS-PAGESee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nBiologically active:No,\u003cbr\u003e\nAccession:P03090,\u003cbr\u003e\nAnimal free:No,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nSpecies:Murine polyomavirus strain A2,\u003cbr\u003e\nReconstitution:Reconstitute in water,\u003cbr\u003e\nStorage buffer:Constituents: PBS\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe Polyomavirus strain RA Major Capsid VP1 is a structural protein essential for viral capsid formation often referred to simply as VP1. It has a molecular mass of approximately 42 kDa. This protein is a primary component of the virus's outer shell or capsid which encapsidates the viral DNA protecting it from degradation. Expression of VP1 occurs during the late phase of the polyomavirus lifecycle in infected host cells particularly within the nucleus where capsid assembly takes place.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nPolyomavirus Major Capsid VP1 serves critical roles in virus assembly and host cell entry. As a principal capsid protein it associates with other capsid proteins VP2 and VP3 forming a complex important for virion structure. This complex facilitates the recognition and attachment to host cell receptors initiating viral entry via endocytosis. VP1's ability to self-assemble into capsids makes it a model for studying virus-like particle formation in various research contexts.\u003cbr\u003e\nPathways\u003cbr\u003e\nMajor Capsid VP1 predominantly participates in the endocytosis pathway which enables the virus to infiltrate host cells. This infiltration relies on interaction with the host cell's surface gangliosides like GM1 a receptor in the endocytosis pathway facilitating transport to the endoplasmic reticulum for viral uncoating. VP1's involvement in this pathway intersects with cellular proteins such as clathrin vital for forming vesicles during endocytosis and trafficking within the cell.\u003cbr\u003e\nPolyomavirus Major Capsid VP1 associates with diseases such as progressive multifocal leukoencephalopathy (PML) a demyelinating disease often seen in immunocompromised individuals. In PML the JC virus another member of the Polyomavirus family with a similar VP1 protein infects oligodendrocytes leading to neuronal damage. This capsid protein also relates to Merkel cell carcinoma where Merkel cell polyomavirus integrates into the host genome driving oncogenesis. VP1’s function connects with proteins involved in immune evasion contributing to disease progression and severity.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46843901903017,"sku":"ab74571","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab74571","provider":"Iright","version":"1.0","type":"link"}