{"product_id":"abcam-ab76238","title":"Abcam, ab76238, Anti-cAMP Protein Kinase Catalytic subunit antibody [EP2102Y]","description":"\u003cp\u003eSize: 20µL \/ 100µL \/ 1mL\u003cbr\u003e\nAnti-cAMP Protein Kinase Catalytic subunit antibody [EP2102Y] (ab76238) is a rabbit monoclonal antibody detecting cAMP Protein Kinase Catalytic subunit in  Western Blot, Flow Cytometry, IP, IHC-P, ICC\/IF . Suitable for  Human, Mouse, Rat . - Biophysical QC for unrivalled batch-batch consistency - Over 20 publications - Trusted since 2009\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EP2102Y,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Rat, Human,\u003cbr\u003e\nApplications:Flow Cyt (Intra), ICC\/IF, IHC-P, WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.,\u003cbr\u003e\nSpecificity:The immunogen used for this product shares 92% homology with PKA C-beta and PKA C-gamma. Cross-reactivity with these proteins have not been confirmed experimentally.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nWhat is this antibody validated in?\u003cbr\u003e\nAnti-cAMP Protein Kinase Catalytic subunit antibody [EP2102Y] (ab76238) is a rabbit recombinant monoclonal antibody and is validated for use in Western Blot (WB), Flow Cytometry (Intra), Flow Cytometry (Flow Cyt), Immunoprecipitation (IP), Immunohistochemistry (IHC-P), Immunocytochemistry\/immunofluorescence (ICC\/IF) in Human, Mouse, Rat samples.\u003cbr\u003e\nWhat is the molecular weight of cAMP Protein Kinase Catalytic subunit?\u003cbr\u003e\nAnti-cAMP Protein Kinase Catalytic subunit [EP2102Y] (ab76238) specifically detects a band for cAMP Protein Kinase Catalytic subunit (UniProt: P17612) at a molecular weight of 46kDa.\u003cbr\u003e\nTrusted by the scientific community\u003cbr\u003e\nAnti-cAMP Protein Kinase Catalytic subunit [EP2102Y] (ab76238) was first used in a scientific publication in 2009 and has been cited over 20 times in peer-reviewed journals.\u003cbr\u003e\nTrial sizes available!\u003cbr\u003e\nTest your antibody or perform pre-screening before committing to a larger quantity. Sold in 10µl.\u003cbr\u003e\nDiscover our selection of trial-size antibodies.\u003cbr\u003e\nOther related products\u003cbr\u003e\nWe have a range of other formats of antibody clone [EP2102Y] also available for your convenience: ab76238, Carrier free -\u003cbr\u003e\nab235385\u003cbr\u003e\n, Alexa Fluor® 647 -\u003cbr\u003e\nab252098\u003cbr\u003e\n, PE -\u003cbr\u003e\nab252099\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb\u003cbr\u003e\npatents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe cAMP Protein Kinase Catalytic subunit also known as protein kinase A (PKA) catalytic subunit plays an important role as an enzyme that phosphorylates various target proteins. This is an important component of the protein kinase A signaling pathway. The subunit has an approximate mass of 40 kDa and is widely expressed in multiple tissues across the body allowing it to affect numerous physiological functions. As a catalytic subunit of cAMP-dependent protein kinase it forms part of the larger enzyme complex that is activated by the binding of cAMP.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe catalytic subunit of protein kinase A modulates cellular processes by transferring a phosphate group from ATP to specific serine\/threonine residues on substrates. It is part of a holoenzyme complex composed of two regulatory and two catalytic subunits; when cAMP binds to the regulatory subunits it releases the catalytic subunits allowing them to execute their activity. This release and activation result in the regulation of glycogen sugar and lipid metabolism among others.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe cAMP Protein Kinase integrates deeply into the cAMP signaling and MAPK\/ERK pathways. These pathways regulate various processes like cell growth differentiation and apoptosis. The catalytic subunit acts downstream of cAMP generation by adenylyl cyclase interacting with other proteins such as CREB (cAMP response element-binding protein) which directly affects transcription and gene expression.\u003cbr\u003e\nThe cAMP Protein Kinase catalytic subunit has been linked to conditions including Carney complex and Cushing's syndrome. Mutations affecting this subunit can lead to dysregulated cAMP signaling impacting proteins like regulatory subunit PRKAR1A that are important in controlling PKA activity. Conditions such as these often arise from aberrations in cAMP signaling pathways reflecting the extensive influence of the cAMP Protein Kinase on homeostasis and disease.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46848364642473,"sku":"ab76238","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab76238","provider":"Iright","version":"1.0","type":"link"}