{"product_id":"abcam-ab8327","title":"Abcam, ab8327, Anti-HIV protease antibody [1696]","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nMouse Monoclonal POL antibody. Suitable for Dot and reacts with Synthetic peptide samples. Cited in 8 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Mouse,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:1696,\u003cbr\u003e\nIsotype:IgG1,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nApplications:DotSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nSpecificity:The antibody recognizes free N-terminus of mature HIV protease (HIV-1 and HIV-2). The antibody does not react with the precursor.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Preservative: 0.098% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nHIV protease also known as aspartyl protease or protein catabolite is an enzyme vital for the maturation of the HIV virus. It is a homodimer each monomer having a mass of about 11 kilodaltons contributing to a total mass of roughly 22 kilodaltons. This enzyme is specifically expressed in HIV-infected cells where it plays a critical role in the life cycle of the virus. HIV protease cleaves newly synthesized polyproteins at specific sites to create the mature protein components of the infectious HIV particle.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nHIV protease is essential for the production of functional viral proteins facilitating viral particle assembly. It is not part of a larger complex but acts on its own to ensure correct protein maturation. Without the activity of this protease the virus cannot replicate efficiently as it fails to produce infectious viral particles. This makes HIV protease an ideal target for antiretroviral drugs which aim to inhibit its function and hinder the progression of the virus.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe HIV protease plays a core role in the viral replication and maturation pathway essential for generating infectious virions. It interacts directly with the gag and gag-pol polyprotein precursors cleaving them into functional units necessary for structural components and replication machinery of the virus. Besides its action upon these precursor proteins integrates it tightly into the intricate machinery of HIV's lifecycle ensuring that all viral components become functionally active for subsequent infections.\u003cbr\u003e\nHIV protease is intimately associated with the Human Immunodeficiency Virus (HIV) infection that leads to Acquired Immunodeficiency Syndrome (AIDS). This enzyme represents a critical target for antiretroviral therapy including protease inhibitors which aim to block its activity and viral replication. The enzyme's inhibition reduces viral load therefore managing the progression of the disease. Moreover resistance mutations in HIV protease can influence the effectiveness of protease inhibitors linking it to challenges in long-term HIV treatment strategies.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46860540969129,"sku":"ab8327","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab8327","provider":"Iright","version":"1.0","type":"link"}